Description

4-(Piperidin-4-Yl)Benzonitrile Hydrochloride is a high-purity, versatile pharmaceutical intermediate and building block. Its molecular structure, featuring a benzonitrile moiety linked to a piperidine ring, makes it a critical precursor in the synthesis of complex bioactive molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new therapeutic agents and crop protection products.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of drug candidates, particularly those targeting central nervous system (CNS) disorders, kinase inhibitors, and other receptor modulators.
• Agrochemical Research: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its heterocyclic structure.
• Chemical Synthesis: Serves as a versatile precursor for further functionalization, enabling the creation of diverse chemical libraries for high-throughput screening.
• Academic & R&D: Employed in medicinal chemistry research for structure-activity relationship (SAR) studies and the exploration of new pharmacophores.
• Material Science: Potential use as a monomer or precursor in the synthesis of specialty polymers and advanced organic materials.

Basic Information

Product Name	4-(Piperidin-4-Yl)Benzonitrile Hydrochloride
CAS No.	162997-34-4
Molecular Formula	C12H15N2·HCl
Molecular Weight	222.72 g/mol (Free base: 186.26 g/mol)
Synonyms	4-(4-Piperidinyl)benzonitrile hydrochloride; 4-Cyano-4'-piperidinobenzene hydrochloride; 4-Piperidin-4-yl-benzonitrile HCl; 1-(4-Cyanophenyl)piperidin-4-ium chloride; Benzonitrile, 4-(4-piperidinyl)-, hydrochloride; 4-(Piperidin-4-yl)benzonitrile monohydrochloride
EINECS	Contact for details

Quality Control

Our 4-(Piperidin-4-Yl)Benzonitrile Hydrochloride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide detailed Certificates of Analysis (COA) with key parameters including assay (HPLC), related substances, residual solvents, and appearance. Our quality commitment supports compliance with cGMP and ICH guidelines for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Related Substances (HPLC)	Total impurities ≤2.0%
Loss on Drying	≤1.0%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.