Description

1-Bromo-4-(Bromomethyl)-2,3-Difluorobenzene, also known as Alpha,4-Dibromo-2,3-Difluorotoluene, is a high-value, multi-functional halogenated aromatic building block. This compound is critical for introducing bromine and difluoromethyl functionalities into complex molecular architectures, enabling precise structural modifications. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for synthesizing novel active ingredients and advanced intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly those requiring halogenated aromatic cores for enhanced bioactivity or metabolic stability.
• Agrochemical Synthesis: Used in the development of new herbicides, fungicides, and insecticides, where the difluorobenzene moiety can improve compound efficacy and environmental profile.
• Liquid Crystal & OLED Material Research: Serves as a building block for creating advanced organic electronic materials, including charge-transport layers and emissive dopants.
• Cross-Coupling Reactions: An excellent substrate for palladium-catalyzed reactions like Suzuki, Stille, or Negishi couplings, facilitating the construction of complex biaryl systems.
• Functional Polymer Monomer: Can be incorporated into polymer backbones to impart specific properties such as flame retardancy or altered refractive index.
• Organic Synthesis & Chemical Research: A versatile reagent for academic and industrial research in medicinal chemistry and material science.

Basic Information

Product Name	1-Bromo-4-(Bromomethyl)-2,3-Difluorobenzene
CAS No.	162744-56-1
Molecular Formula	C7H4Br2F2
Molecular Weight	285.91 g/mol
Synonyms	Alpha,4-Dibromo-2,3-Difluorotoluene; 4-Bromo-2,3-difluorobenzyl bromide; 2,3-Difluoro-4-bromobenzyl bromide; 1-Bromo-4-(bromomethyl)-2,3-difluorobenzene; (4-Bromo-2,3-difluorophenyl)methyl bromide; 2,3-Difluoro-α,4-dibromotoluene
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Bromomethyl)-2,3-Difluorobenzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, and NMR, to ensure high purity and batch-to-batch consistency suitable for sensitive synthetic applications. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.