Description

n-(4-Nitrophenoxycarbonyl)-L-Valine Methyl Ester is a specialized amino acid derivative and a key activated ester intermediate in organic synthesis. This compound is valued for its role in facilitating efficient peptide coupling reactions under mild conditions. It is primarily utilized by researchers and manufacturers in the pharmaceutical and biotechnology sectors for the development of novel peptide-based therapeutics and fine chemicals.

Application

• Peptide Synthesis: Serves as a crucial activated ester intermediate for the controlled formation of peptide bonds in solid-phase and solution-phase synthesis.
• Pharmaceutical Intermediates: Used in the research and production of active pharmaceutical ingredients (APIs), particularly for peptide and peptidomimetic drugs.
• Bioconjugation: Acts as a reagent for labeling biomolecules, such as proteins and antibodies, with various probes or tags for diagnostic and research applications.
• Chemical Biology Research: Employed as a building block or tool compound in the study of enzyme mechanisms, protein-protein interactions, and metabolic pathways.
• Fine Chemical Production: Utilized in the synthesis of complex, high-value organic molecules requiring the selective introduction of a valine moiety.

Basic Information

Product Name	n-(4-Nitrophenoxycarbonyl)-L-Valine Methyl Ester
CAS No.	162537-10-2
Molecular Formula	C14H16N2O6
Molecular Weight	308.29 g/mol
Synonyms	L-Valine, N-[(4-nitrophenoxy)carbonyl]-, methyl ester; Methyl N-[(4-nitrophenoxy)carbonyl]-L-valinate; 4-Nitrophenyl N-(methoxycarbonyl)-L-valinyl carbonate; p-Nitrophenyl N-(methoxycarbonyl)-L-valinate carbonate; Activated L-Valine Methyl Ester; Val-ONp-OMe; (S)-Methyl 2-((((4-nitrophenoxy)carbonyl)amino)-3-methylbutanoate
EINECS	Contact for details

Quality Control

Our n-(4-Nitrophenoxycarbonyl)-L-Valine Methyl Ester is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and chiral integrity, to ensure it meets the high standards required for research and pharmaceutical applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is light-sensitive and should be handled accordingly to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.