Description

1,4,7,10-Tetraaza-Cyclododecane-1,7-Dicarboxylic Acid Dibenzyl Ester is a sophisticated macrocyclic intermediate of significant importance in advanced organic synthesis. This compound serves as a critical precursor for the development of functionalized cyclen derivatives, which are foundational in coordination chemistry and materials science. It is primarily utilized by research institutions and industrial R&D departments focused on creating novel chelating agents, catalysts, and molecular imaging probes.

Application

• Precursor for MRI Contrast Agents: A key building block in synthesizing macrocyclic ligands for gadolinium-based contrast media used in magnetic resonance imaging (MRI).
• Coordination Chemistry Research: Used to develop high-stability metal complexes for catalytic applications and as models for bioinorganic studies.
• Radiopharmaceutical Synthesis: Serves as an intermediate for chelators that bind radioisotopes (e.g., 64Cu, 68Ga) for diagnostic and therapeutic nuclear medicine.
• Material Science: Employed in the creation of functionalized surfaces, sensors, and advanced polymeric materials with metal-binding capabilities.
• Chemical Biology Probes: Used to synthesize fluorescent or luminescent tags for tracking biological molecules and cellular processes.

Basic Information

Product Name	1,4,7,10-Tetraaza-Cyclododecane-1,7-Dicarboxylic Acid Dibenzyl Ester
CAS No.	162148-45-0
Molecular Formula	C26H34N4O4
Molecular Weight	466.58 g/mol
Synonyms	1,7-Dibenzyl 1,4,7,10-tetraazacyclododecane-1,7-dicarboxylate; 1,4,7,10-Tetraazacyclododecane-1,7-dicarboxylic Acid, Dibenzyl Ester; Cyclen-1,7-dicarboxylic Acid Dibenzyl Ester; 1,7-Di(benzyloxycarbonyl)-1,4,7,10-tetraazacyclododecane; DO2A Dibenzyl Ester; 1,4,7,10-Tetraazacyclododecane-1,7-dicarboxylic Acid Dibenzyl Ester; 1,7-Di(Boc)-Cyclen Dibenzyl Ester Derivative
EINECS	Contact for details

Quality Control

Our production of 1,4,7,10-Tetraaza-Cyclododecane-1,7-Dicarboxylic Acid Dibenzyl Ester adheres to stringent quality protocols suitable for research and pharmaceutical intermediate applications. Each batch is characterized and tested to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and impurity profiles are provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (typically 15-25°C). This compound is moisture-sensitive (hygroscopic); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity	≥ 99.0% ee
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm
Water Content (KF)	< 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.