Description

8-(((Trifluoromethyl)Sulfonyl)Oxy)-2-(n-Propylamino)Tetralin is a high-purity, advanced pharmaceutical intermediate characterized by its unique trifluoromethanesulfonate (triflate) ester and tetralin-based amine structure. This compound matters for its critical role as a versatile building block in the synthesis of complex organic molecules, particularly in medicinal chemistry research and development. Pharmaceutical companies and contract research organizations (CROs) specializing in central nervous system (CNS) agents and other therapeutic areas require this intermediate for its reactive triflate group, which facilitates efficient carbon-carbon and carbon-heteroatom bond formation.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting neurological and psychiatric disorders.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization due to its reactive triflate leaving group.
• Organic Synthesis Building Block: Employed in cross-coupling reactions (e.g., Suzuki, Stille) to introduce complex tetralin-amine scaffolds into target molecules.
• Chemical Reference Standard: Serves as an analytical standard for quality control and method development in API manufacturing.
• Preclinical Development: Utilized in the production of compounds for pharmacological evaluation and toxicology studies.

Basic Information

Product Name	8-(((Trifluoromethyl)Sulfonyl)Oxy)-2-(n-Propylamino)Tetralin
CAS No.	161970-95-2
Molecular Formula	C14H18F3NO3S
Molecular Weight	337.36 g/mol
Synonyms	2-(N-Propylamino)-8-[(trifluoromethyl)sulfonyl]oxytetralin; 8-[(Trifluoromethyl)sulfonyl]oxy-2-(propylamino)tetralin; 2-(Propylamino)-8-trifluoromethanesulfonyloxytetralin; 8-Trifluoromethanesulfonyloxy-2-propylaminotetralin; 8-OTf-2-(n-Propylamino)tetralin; N-Propyl-8-triflyloxytetralin-2-amine
EINECS	Contact for details

Quality Control

Our 8-(((Trifluoromethyl)Sulfonyl)Oxy)-2-(n-Propylamino)Tetralin is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for assay and purity, and is supplied with a detailed Certificate of Analysis (COA). We adhere to cGMP principles where applicable to support its use in regulated research and development pipelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The container should be kept tightly sealed to protect the material from moisture.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.