Description

2,3,4,5,6-Pentafluorophenyl 4-Chlorobenzenesulphonate is a high-purity, specialty fluorinated sulfonate ester, a critical building block in advanced organic synthesis. Its unique structure, featuring a perfluorinated phenyl group and a chlorobenzenesulfonyl moiety, makes it an exceptionally reactive and versatile electrophile for introducing sulfonate ester functionalities. This compound is essential for researchers and manufacturers in the pharmaceutical, agrochemical, and materials science industries, where it is used to create novel active ingredients and functional materials with tailored properties.

Application

• Pharmaceutical Intermediate: Key reagent in the synthesis of active pharmaceutical ingredients (APIs), particularly for constructing complex sulfonamide and sulfonate ester derivatives.
• Agrochemical Synthesis: Used as a building block for developing new herbicides, fungicides, and insecticides with enhanced efficacy and environmental profiles.
• Liquid Crystal & OLED Materials: Serves as a precursor for synthesizing fluorinated charge-transport materials and liquid crystal compounds for electronic displays.
• Polymer Modification: Employed to introduce sulfonate ester groups into polymer backbones, altering solubility, thermal stability, and surface properties.
• Cross-Coupling Reactions: Acts as an effective electrophilic partner in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Stille) to form biaryl systems.
• Protecting Group Chemistry: Utilized as a robust protecting group for alcohols and phenols in multi-step synthetic sequences.
• Chemical Biology Probes: Used in the development of activity-based probes and affinity labels for studying enzyme function.

Basic Information

Item	Details
Product Name	2,3,4,5,6-Pentafluorophenyl 4-Chlorobenzenesulphonate
CAS No.	161759-99-5
Molecular Formula	C12H4ClF5O3S
Molecular Weight	358.67 g/mol
Synonyms	4-Chlorobenzenesulfonic Acid 2,3,4,5,6-Pentafluorophenyl Ester; Pentafluorophenyl 4-Chlorobenzenesulfonate; 4-Chlorophenylsulfonyl Pentafluorophenyl Ester; 4-Chlorobenzenesulfonyl Pentafluorophenyl Ester; 4-Chlorobenzene-1-sulfonic Acid Pentafluorophenyl Ester; PFP-4-Chlorobenzenesulfonate; PFPCBS
EINECS	Contact for details

Quality Control

Every batch of 2,3,4,5,6-Pentafluorophenyl 4-Chlorobenzenesulphonate is manufactured under strict quality management systems. We employ advanced analytical techniques, including HPLC, GC, NMR, and MS, to ensure identity, purity, and consistency meet the exacting standards required for research and commercial synthesis. A comprehensive Certificate of Analysis (COA) detailing purity, impurity profile, and physical characteristics is provided with each shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Heavy Metals	≤ 10 ppm
Single Impurity (HPLC)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.