Description

(R)-n-(2,2-Difluoroethylidene)-1-Phenylethylamine CAS NO 160797-29-5 is a chiral amine building block featuring a difluoroethylidene moiety, offering unique reactivity and stereochemical control for advanced synthesis. This compound is valued for its role as a key intermediate in the development of pharmaceuticals and agrochemicals, where its specific stereochemistry and fluorine atoms are critical for bioactivity and metabolic stability. It is primarily needed by research and development chemists, process development scientists, and manufacturers in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS disorders, oncology, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides, where the fluorine atoms enhance lipophilicity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for chiral ligands and organocatalysts used in asymmetric synthesis to induce high enantioselectivity.
• Fine Chemical Production: Employed in the multistep synthesis of complex, high-value specialty chemicals for electronics and material science applications.
• Academic and Industrial R&D: A valuable reagent for method development and exploring new synthetic pathways in organic and fluorine chemistry.
• Process Chemistry: Used in scale-up and optimization studies for the commercial manufacturing of fluorinated chiral compounds.

Basic Information

Product Name	(R)-n-(2,2-Difluoroethylidene)-1-Phenylethylamine
CAS No.	160797-29-5
Molecular Formula	C10H11F2N
Molecular Weight	183.20 g/mol
Synonyms	(R)-1-Phenylethyl-2,2-difluoroethylideneamine; (R)-N-(2,2-Difluoroethylidene)-α-methylbenzylamine; (R)-N-(1-Phenylethyl)-2,2-difluoroethanimine; (R)-α-Methylbenzyl 2,2-difluoroethylideneamine; (R)-DFEA; (R)-Difluoroethylidenephenylethylamine
EINECS	Contact for details

Quality Control

Our (R)-n-(2,2-Difluoroethylidene)-1-Phenylethylamine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with data for chiral purity, assay, and impurity profiles. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliable supply and traceability for critical R&D and production applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to protect from moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.