Description

3-Chloro-6-Ethynylpyridazine is a versatile and high-value heterocyclic building block characterized by its reactive ethynyl and chloro substituents. This compound matters for its critical role in facilitating advanced synthetic transformations, particularly in the construction of complex molecular architectures via cross-coupling and cycloaddition reactions. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, especially for kinase inhibitors and other targeted therapies.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators.
• Material Science Building Block: Employed in the creation of specialized polymers, ligands for catalysis, and organic electronic materials.
• Cross-Coupling Reactions: Serves as a substrate in Sonogashira, Suzuki-Miyaura, and other palladium-catalyzed coupling reactions to form carbon-carbon bonds.
• Click Chemistry: The ethynyl group makes it an ideal participant in Huisgen 1,3-dipolar cycloadditions (click chemistry) for bioconjugation and library synthesis.
• Chemical Biology Probe Development: Used to create molecular probes for studying biological processes and enzyme functions.

Basic Information

Product Name	3-Chloro-6-Ethynylpyridazine
CAS No.	160510-68-9
Molecular Formula	C6H3ClN2
Molecular Weight	138.56 g/mol
Synonyms	6-Ethynyl-3-chloropyridazine; 3-Chloro-6-ethynyl-1,2-diazine; 3-Chloro-6-ethynylpyridazine; 160510-68-9; 3-Chloro-6-ethinylpyridazine
EINECS	Contact for details

Quality Control

Our 3-Chloro-6-Ethynylpyridazine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing specifications such as assay (by HPLC), impurity profile, and physical characteristics. Our quality commitment supports compliance with cGMP and ICH guidelines for advanced pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and light-sensitive; therefore, containers must be kept sealed under an inert atmosphere (e.g., nitrogen or argon) when not in use to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.