Description

1-[[(4-Methylphenyl)Sulphonyl]Oxy]-1,2-Benziodoxol-3(1H)-One is a specialized hypervalent iodine(III) reagent, a key class of compounds valued for their powerful and selective oxidative properties. This compound matters for enabling efficient and high-yielding transformations in complex organic synthesis, particularly in the construction of challenging molecular architectures. It is primarily needed by research and development chemists in the pharmaceutical and agrochemical industries for advanced intermediate synthesis, as well as by academic institutions exploring novel synthetic methodologies.

Application

• Oxidative Functionalization: Used as a selective oxidant for the functionalization of C-H bonds in complex molecules.
• Heterocycle Synthesis: A key reagent in the construction of oxygen- and nitrogen-containing heterocyclic scaffolds important for active pharmaceutical ingredients (APIs).
• Cross-Coupling Reactions: Facilitates metal-free or transition-metal-catalyzed cross-coupling reactions under mild conditions.
• Ligand Exchange & Transfer: Acts as an efficient source for the transfer of the tosyloxy (OTs) or other functional groups in hypervalent iodine chemistry.
• Pharmaceutical Intermediate Synthesis: Employed in the late-stage diversification and synthesis of high-value drug candidates and intermediates.
• Agrochemical Research: Applied in the synthesis of novel bioactive compounds for crop protection research.
• Material Science Precursor: Serves as a precursor for generating reactive intermediates used in polymer and advanced material development.
• Methodology Development: A valuable tool for academic and industrial researchers developing new synthetic protocols in organic chemistry.

Basic Information

Product Name	1-[[(4-Methylphenyl)Sulphonyl]Oxy]-1,2-Benziodoxol-3(1H)-One
CAS No.	159950-96-6
Molecular Formula	C14H11IO5S
Molecular Weight	418.20 g/mol
Synonyms	(1-Hydroxy-1,2-benziodoxol-3(1H)-one 1-oxide) 4-methylbenzenesulfonate; 1-Tosyloxy-1,2-benziodoxol-3(1H)-one; Benziodoxole Tosylate Reagent; TIB-OTs; [Hydroxy(tosyloxy)iodo]benzene Cyclic Derivative; 1,2-Benziodoxol-3(1H)-one, 1-[[(4-methylphenyl)sulfonyl]oxy]-; Hypervalent Iodine(III) Tosylate Reagent
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide high-purity grades suitable for research and development, with typical purity levels exceeding 95% (HPLC). Each batch is characterized by NMR, IR, and HPLC to confirm identity and purity. Certificates of Analysis (COA) detailing all specifications are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Loss on Drying	≤ 2.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.