Description

1-(2-Methoxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2(3H)-One is a high-value, multi-trifluoromethylated benzimidazolone derivative, a key structural motif prized for its unique electronic and steric properties. This compound matters as a sophisticated pharmaceutical intermediate and agrochemical building block, where the presence of trifluoromethyl groups significantly enhances biological activity, metabolic stability, and lipophilicity. It is primarily needed by R&D chemists and process development teams in the pharmaceutical, agrochemical, and advanced material sectors for synthesizing novel active ingredients.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of novel drug candidates, particularly in oncology, antiviral, and central nervous system (CNS) therapeutic areas.
• Agrochemical Active Ingredient Synthesis: Serves as a key building block for developing next-generation herbicides, fungicides, and insecticides with improved efficacy and environmental profile.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and organic electronic materials due to its electron-withdrawing characteristics.
• Chemical Biology Probe Development: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and as a scaffold for enzyme inhibitors.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for scale-up and production under cGMP conditions.

Basic Information

Product Name	1-(2-Methoxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2(3H)-One
CAS No.	159117-83-6
Molecular Formula	C16H10F6N2O2
Molecular Weight	376.26 g/mol
Synonyms	5-(Trifluoromethyl)-1-[2-methoxy-5-(trifluoromethyl)phenyl]-1,3-dihydro-2H-benzimidazol-2-one; 1-(2-Methoxy-5-(trifluoromethyl)phenyl)-5-(trifluoromethyl)-1H-benzimidazol-2(3H)-one; 2(3H)-Benzimidazolone, 1-[2-methoxy-5-(trifluoromethyl)phenyl]-5-(trifluoromethyl)-; 159117-83-6; Benzimidazolone derivative with trifluoromethyl groups; Trifluoromethyl benzimidazolone intermediate.
EINECS	Contact for details

Quality Control

Our production of 1-(2-Methoxy-5-(Trifluoromethyl)Phenyl)-5-(Trifluoromethyl)-1H-Benzo[D]Imidazol-2(3H)-One adheres to stringent quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We support development and commercial projects with material suitable for research use through to cGMP-grade manufacturing, with full traceability and documentation.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). The compound may be light-sensitive and should be handled under an inert atmosphere for long-term storage to prevent potential degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Any single impurity ≤ 0.5%, Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.