Description

Maleimidoethyl 3-(Tri-n-Butylstannyl)Hippurate is a specialized organotin reagent featuring a maleimide functional group, designed for targeted bioconjugation and labeling applications. This compound is critical for researchers and manufacturers requiring precise, covalent attachment of probes, drugs, or other molecules to thiol-containing biomolecules. It is primarily utilized in the development of antibody-drug conjugates (ADCs), diagnostic assays, and advanced materials within the pharmaceutical, biotechnology, and life sciences research sectors.

Application

• Antibody-Drug Conjugate (ADC) Linker Chemistry: Serves as a key heterobifunctional crosslinker for site-specific conjugation of cytotoxic payloads to monoclonal antibodies via thiol-maleimide chemistry.
• Protein and Peptide Labeling: Enables the covalent attachment of fluorescent dyes, biotin, or other tags to cysteine residues in proteins and peptides for imaging and detection.
• Surface Functionalization: Used to modify nanoparticles, biosensors, and chromatographic supports with maleimide groups for subsequent immobilization of thiolated ligands or biomolecules.
• Polymer Synthesis: Acts as a functional monomer or end-group in the synthesis of smart polymers and hydrogels with reactive sites for bioconjugation.
• Diagnostic Reagent Development: Integral in creating labeled antibodies and antigens for ELISA, lateral flow assays, and other immunoassay platforms.
• Chemical Biology Probes: Employed in the synthesis of activity-based probes for studying enzyme function and protein-protein interactions.

Basic Information

Product Name	Maleimidoethyl 3-(Tri-n-Butylstannyl)Hippurate
CAS No.	158745-44-9
Molecular Formula	C30H48N2O5Sn
Molecular Weight	635.41 g/mol
Synonyms	3-(Tri-n-butylstannyl)hippuric acid N-(2-maleimidoethyl)amide; N-(2-Maleimidoethyl)-3-(tributylstannyl)hippuramide; Maleimido-C2-SnBu3-Hippurate; Tributylstannyl Hippurate Maleimide; Hippur-3-yltributylstannane Maleimide Derivative; ADC Linker with Organotin Handle; Thiol-reactive Organotin Reagent
EINECS	Contact for details

Quality Control

Every batch of Maleimidoethyl 3-(Tri-n-Butylstannyl)Hippurate is manufactured and analyzed under strict quality management systems. We provide comprehensive analytical data including HPLC purity, NMR and mass spectrometry confirmation to ensure structural integrity and batch-to-batch consistency. Certificates of Analysis (COA) detailing all specifications are available upon request, supporting compliance in GMP and research-grade applications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (argon or nitrogen) to prevent oxidation and hydrolysis. Allow the sealed container to reach room temperature before opening to minimize moisture condensation. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.