Description

8-Azabicyclo[3.2.1]Octane-2-Carboxylic Acid, 8-Methyl-3-[4-(Trimethyl-Stannyl)Phenyl]-, Methyl Ester, [1R-(Exo, Exo)]- is a high-value, stereochemically defined organotin intermediate featuring a complex tropane-derived bicyclic framework. This compound matters for its role as a critical building block in advanced organic synthesis, particularly in cross-coupling reactions enabled by its trimethylstannyl moiety. It is primarily needed by pharmaceutical R&D and fine chemical synthesis teams developing novel active pharmaceutical ingredients (APIs) and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of complex drug candidates, particularly those targeting the central nervous system (CNS).
• Stille Cross-Coupling Reactions: The trimethylstannyl group acts as a versatile handle for forming carbon-carbon bonds with aryl or vinyl halides under palladium catalysis.
• Advanced Organic Synthesis: Used in constructing sophisticated, nitrogen-containing bicyclic scaffolds for medicinal chemistry and chemical biology research.
• Ligand and Catalyst Development: Potential use in the development of novel chiral ligands or organometallic catalysts due to its rigid, three-dimensional structure.
• Radiopharmaceutical Precursor: The organotin group can be a precursor for radioiodination or other radiolabeling techniques in diagnostic agent development.
• Material Science Research: Exploration of its use in creating novel organic materials with specific electronic or structural properties.

Basic Information

Product Name	8-Azabicyclo[3.2.1]Octane-2-Carboxylic Acid, 8-Methyl-3-[4-(Trimethyl-Stannyl)Phenyl]-, Methyl Ester, [1R-(Exo, Exo)]-
CAS No.	158111-10-5
Molecular Formula	C19H27NO2Sn
Molecular Weight	420.13 g/mol
Synonyms	(1R,2R,3S,5S)-8-Methyl-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester; Methyl (1R,2R,3S,5S)-3-[4-(trimethylstannyl)phenyl]-8-methyl-8-azabicyclo[3.2.1]octane-2-carboxylate; [1R-(exo,exo)]-8-Methyl-3-[4-(trimethylstannyl)phenyl]-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester; 8-Methyl-3-(4-trimethylstannylphenyl)-8-azabicyclo[3.2.1]octane-2-carboxylic acid methyl ester, endo-; Tropane-2-carboxylic acid, 3-(4-(trimethylstannyl)phenyl)-, methyl ester, (1R,2R,3S,5S)-rel-; Organotin tropane derivative; Stannylated tropane ester.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and purity essential for sensitive coupling reactions. Quality is verified through comprehensive analytical techniques including HPLC, NMR (1H, 13C, 119Sn), and GC-MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen). The compound is moisture-sensitive and should be handled in a dry environment. Keep away from strong oxidizers and acids.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.