Description

2H-Pyran-2-Carboxylicacid,4-Fluorotetrahydro-,Methylester,cis-(9Ci) is a fluorinated heterocyclic ester building block of significant interest in advanced organic synthesis. Its value lies in its cis-configured, functionalized pyran ring, which serves as a versatile precursor for creating complex molecular architectures. This compound is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the development of novel active ingredients and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the research and development of fluorinated drug candidates, particularly in central nervous system (CNS) and antiviral therapies.
• Agrochemical Synthesis: Used in the creation of novel, fluorinated pesticides and herbicides, where the fluorine atom can enhance biological activity and stability.
• Advanced Material Research: Serves as a monomer or precursor for specialty polymers and liquid crystals with tailored optical or electronic properties.
• Asymmetric Catalysis: Employed as a substrate or ligand precursor in the development of new catalytic systems for stereoselective transformations.
• Chemical Biology Probes: Utilized to synthesize fluorinated analogs of natural products for metabolic pathway studies and target identification.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for client-specific, multi-step synthesis projects.

Basic Information

Product Name	2H-Pyran-2-Carboxylicacid,4-Fluorotetrahydro-,Methylester,cis-(9Ci)
CAS No.	157919-83-0
Molecular Formula	C7H9FO3
Molecular Weight	160.14 g/mol
Synonyms	cis-4-Fluorotetrahydro-2H-pyran-2-carboxylic acid methyl ester; Methyl cis-4-fluorotetrahydro-2H-pyran-2-carboxylate; (2R,4S)- and (2S,4R)-4-Fluorotetrahydro-2H-pyran-2-carboxylic acid methyl ester; 4-Fluoro-tetrahydro-pyran-2-carboxylic acid methyl ester; Fluorinated THP ester; 157919-83-0; cis-4-Fluoro-tetrahydropyran-2-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Every batch of our 2H-Pyran-2-Carboxylicacid,4-Fluorotetrahydro-,Methylester,cis-(9Ci) is manufactured under strict quality management systems. We employ advanced analytical techniques including HPLC, GC, NMR, and MS to ensure identity, purity, and enantiomeric/excess where specified. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. For long-term storage, consider an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
cis-Isomer Content (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.