Description

1(6H)-Pyridazinecarboxylic Acid, 6-Ethynyl-, Ethyl Ester is a specialized heterocyclic building block featuring a pyridazine core with an ethynyl substituent. This compound is valued for its unique reactivity, particularly the alkyne group, which enables advanced synthetic transformations like click chemistry and Sonogashira cross-coupling reactions. It is primarily sought by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and complex molecular architectures.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the research and development of new drug candidates, particularly for creating complex heterocyclic scaffolds.
• Agrochemical Synthesis: Used in the design and production of novel pesticides and herbicides, leveraging its structural motifs for biological activity.
• Material Science Research: Acts as a precursor for functionalized polymers or organic electronic materials due to its conjugated ethynyl group.
• Click Chemistry Reagent: The terminal alkyne moiety makes it suitable for Huisgen 1,3-dipolar cycloaddition reactions to efficiently build molecular complexity.
• Cross-Coupling Reactions: Employed in palladium-catalyzed reactions, such as Sonogashira coupling, to form carbon-carbon bonds for advanced synthetic routes.
• Chemical Biology Probes: Utilized in the development of molecular probes and tags for studying biological systems and target engagement.

Basic Information

Product Name	1(6H)-Pyridazinecarboxylic Acid, 6-Ethynyl-, Ethyl Ester
CAS No.	157465-71-9
Molecular Formula	C9H8N2O2
Molecular Weight	176.17 g/mol
Synonyms	Ethyl 6-Ethynyl-1(6H)-pyridazinecarboxylate; 6-Ethynyl-1(6H)-pyridazinecarboxylic Acid Ethyl Ester; 1,6-Dihydro-6-ethynylpyridazine-1-carboxylic Acid Ethyl Ester; 6-Ethynyl-1,6-dihydropyridazine-1-carboxylic Acid Ethyl Ester; 6-Ethynyl-1,6-dihydro-1-pyridazinecarboxylic Acid Ethyl Ester; Ethyl 6-Ethynyl-1,6-dihydropyridazine-1-carboxylate
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with a typical purity of ≥95% (by HPLC), tailored to meet specific research and development requirements. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Our quality management system supports cGMP and ISO standards for reliable, batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (e.g., nitrogen or argon) at controlled room temperature (15-25°C) to minimize oxidation and degradation. This material is easily oxidized; ensure containers are sealed properly after each use to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.