Description

4-Methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate is a high-value, reactive triflate ester building block used in advanced organic synthesis. This compound is critical for introducing the 4-methyl-5-oxo-2,5-dihydrofuran-3-yl moiety into target molecules via cross-coupling reactions or nucleophilic substitutions. It is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of complex heterocyclic compounds, active pharmaceutical ingredients (APIs), and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates and active pharmaceutical ingredients (APIs), particularly those containing functionalized furanone scaffolds.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides, herbicides, and fungicides that require specific heterocyclic frameworks for bioactivity.
• Material Science Research: Serves as a precursor for creating specialized monomers or functional polymers with unique thermal or optical properties.
• Cross-Coupling Reactions: An effective electrophile in Pd-catalyzed cross-coupling reactions (e.g., Suzuki, Stille, Negishi) to form carbon-carbon bonds.
• Nucleophilic Substitution: The triflate group is an excellent leaving group, facilitating nucleophilic attack by various oxygen, nitrogen, and carbon nucleophiles.
• Ligand and Catalyst Development: Utilized in the preparation of novel ligands or organometallic catalysts for asymmetric synthesis.

Basic Information

Product Name	4-Methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate
CAS No.	157123-02-9
Molecular Formula	C7H7F3O5S
Molecular Weight	260.19 g/mol
Synonyms	3-Hydroxy-4-methyl-2(5H)-furanone 3-triflate; 4-Methyl-5-oxo-2,5-dihydro-3-furanyl trifluoromethanesulfonate; 3-Trifluoromethanesulfonyloxy-4-methyl-2(5H)-furanone; 4-Methyl-5-oxo-2,3-dihydrofuran-3-yl triflate; 3-(Trifluoromethylsulfonyloxy)-4-methyl-2(5H)-furanone; 4-Methyl-2,5-dihydro-5-oxofuran-3-yl trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our 4-Methyl-5-oxo-2,5-dihydrofuran-3-yl trifluoromethanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for sensitive synthetic applications. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.