Description

(S)-Tetrahydropyridazine-1,2,3-Tricarboxylic Acid 1,2-Di-tert-Butyl Ester is a high-value chiral building block and protected amino acid derivative. This compound matters for its role in the synthesis of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by pharmaceutical R&D and process chemistry teams for the development of new drug candidates, particularly in the areas of protease inhibitors and other small-molecule therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the research and development of novel active pharmaceutical ingredients (APIs).
• Peptidomimetic Synthesis: Used to construct constrained peptide analogs and protease inhibitor scaffolds.
• Asymmetric Synthesis: Serves as a starting material or intermediate in catalytic asymmetric transformations.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization.
• Chemical Biology: Utilized in the design and synthesis of enzyme inhibitors and molecular probes.
• Custom Synthesis: A critical component for contract research and manufacturing organizations (CROs/CMOs) offering bespoke chemical services.

Basic Information

Product Name	(S)-Tetrahydropyridazine-1,2,3-Tricarboxylic Acid 1,2-Di-tert-Butyl Ester
CAS No.	156699-39-7
Molecular Formula	C16H26N2O6
Molecular Weight	342.39 g/mol
Synonyms	(3S)-1,2,3,6-Tetrahydropyridazine-1,2,3-tricarboxylic acid, 1,2-di-tert-butyl ester; (S)-1,2-Di-tert-butyl 1,2,3,6-tetrahydropyridazine-1,2,3-tricarboxylate; (S)-H-Pyridazine(1,2,3,6-tetra)-Tic(OtBu)2-OH; (S)-1,2,3,6-Tetrahydropyridazine-1,2,3-tricarboxylic Acid 1,2-Di-t-butyl Ester; Fmoc-(S)-1,2,3,6-tetrahydropyridazine-1,2,3-tricarboxylic Acid-1,2-di-tert-butyl Ester (precursor); (S)-Tic(OtBu)2-OH; Chiral Pyridazine Tricarboxylate Derivative
EINECS	Contact for details

Quality Control

Our products undergo rigorous quality testing to ensure compliance with industry standards. We provide material with typical purity of ≥97% (HPLC), with strict control over enantiomeric excess and related substances. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request. Production can adhere to cGMP guidelines for advanced pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is moisture-sensitive (hygroscopic); ensure the container is sealed under an inert atmosphere after opening to maintain stability and prevent degradation.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥97.0%
Enantiomeric Excess (Chiral HPLC)	≥99.0%
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.