Description

2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Ethyl Methanesulfonate is a high-purity, functionalized chemical intermediate featuring a reactive maleimide group linked to a methanesulfonate ester. This compound is critically important for its dual reactivity, enabling precise conjugation and functionalization in advanced material and pharmaceutical synthesis. It is primarily sought by R&D and production teams in the pharmaceutical, bioconjugation, and specialty polymer industries for creating targeted drug delivery systems, diagnostic agents, and cross-linked polymeric networks.

Application

• Bioconjugation Reagent: A key building block for linking peptides, proteins, or antibodies to drugs, dyes, or solid supports via the maleimide-thiol "click" chemistry, followed by further functionalization via the sulfonate ester.
• Pharmaceutical Intermediate: Used in the synthesis of antibody-drug conjugates (ADCs) and other targeted therapeutics where controlled linker chemistry is essential.
• Polymer Cross-linking Agent: Employed in the production of hydrogels and specialty polymers, where it acts as a difunctional monomer to introduce reactive handles or create cross-linked networks.
• Surface Functionalization: Modifies surfaces of nanoparticles, chips, or resins to introduce maleimide groups for subsequent biomolecule immobilization.
• Diagnostic Probe Synthesis: Facilitates the creation of fluorescent or radioactive probes for imaging and diagnostic applications.
• Material Science Research: Serves as a versatile synthon in academic and industrial research for developing novel functional materials.

Basic Information

Product Name	2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Ethyl Methanesulfonate
CAS No.	155863-36-8
Molecular Formula	C8H11NO6S
Molecular Weight	249.24 g/mol
Synonyms	1-[2-(Methylsulfonyloxy)ethyl]-1H-pyrrole-2,5-dione; N-(2-Methanesulfonatoethyl)maleimide; 2-Maleimidoethyl methanesulfonate; Methanesulfonic acid 2-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-ethyl ester; Maleimide-PEG1-Mesylate; MS(PEG)1-Maleimide; Maleimidoethyl mesylate
EINECS	Contact for details

Quality Control

Our 2-(2,5-Dioxo-2,5-Dihydro-1H-Pyrrol-1-Yl)Ethyl Methanesulfonate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research and production applications. Certificates of Analysis (COA) with detailed chromatographic data are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. Keep container tightly sealed in a desiccated environment when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.