Description

4-Chlorobutylzinc Bromide is a versatile organozinc reagent, specifically a functionalized alkylzinc halide, widely used in modern organic synthesis. Its primary value lies in enabling efficient carbon-carbon bond formation, particularly in cross-coupling reactions, which are fundamental for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for developing active ingredients and novel compounds.

Application

• Pharmaceutical Intermediate Synthesis: A key building block for introducing the 4-chlorobutyl moiety into target molecules via Negishi and other transition-metal-catalyzed cross-couplings.
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and plant growth regulators that require specific alkyl chain functionalities.
• Ligand and Catalyst Preparation: Serves as a precursor for synthesizing specialized ligands and organometallic catalysts used in asymmetric synthesis.
• Material Science: Employed in the creation of functionalized polymers and organic electronic materials where precise chain length and terminal halide groups are critical.
• Fine Chemical Production: Facilitates the scalable synthesis of specialty chemicals, flavors, and fragrances through efficient alkylation steps.
• Academic & Process Chemistry: A valuable tool for methodological development and exploring new synthetic pathways in laboratory and pilot-scale settings.

Basic Information

Product Name	4-Chlorobutylzinc Bromide
CAS No.	155589-48-3
Molecular Formula	C4H8BrClZn
Molecular Weight	236.85 g/mol
Synonyms	4-Chlorobutylzinc bromide solution; Bromo(4-chlorobutyl)zinc; Zinc, bromo(4-chlorobutyl)-; (4-Chlorobutyl)zinc bromide; 1-Chloro-4-(bromozincio)butane; 4-Chloro-1-bromozinciobutane; Organozinc reagent C4-Cl; Bromo(4-chlorobutyl)zinc solution
EINECS	Contact for details

Quality Control

Our 4-Chlorobutylzinc Bromide is manufactured under strict quality protocols to ensure batch-to-batch consistency and high reactivity. Each lot undergoes comprehensive analysis, including titration for active zinc content and GC or NMR analysis for purity and identity. A Certificate of Analysis (COA) detailing all test results is provided with every shipment. Our quality management system supports compliance with cGMP and ISO standards for research and development applications.

Storage

Preserve in a tightly closed container, protected from light. Due to its properties of being highly volatile and easily oxidized, this reagent must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. The storage area should be cool, dry, and well-ventilated, away from heat and incompatible materials.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (NMR/IR)	Conforms to structure
Concentration (in solvent)	0.5 M in THF (or as specified)
Assay (Titration)	≥ 95% (as RZnBr)
Purity (GC)	Contact for details
Solvent	Specified (e.g., Tetrahydrofuran)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.