Description

Sodium (2-Sulfonatoethyl)Methanethiosulfonate CAS NO 155450-07-0 is a specialized, water-soluble thiol-reactive reagent used for the site-specific modification of proteins and other biomolecules. This compound is valued for its ability to introduce stable, negatively charged sulfonate groups, which can alter solubility and electrostatic properties. It is primarily required by researchers and manufacturers in the fields of bioconjugation, protein engineering, and diagnostic assay development.

Application

• Bioconjugation Reagent: For the site-specific labeling of cysteine residues in proteins and antibodies to create stable thioether linkages.
• Protein Modification: Used to introduce negative charges (sulfonate groups) onto protein surfaces to improve solubility or alter electrophoretic mobility.
• Crosslinking Agent: In the development of protein-protein or protein-ligand conjugates for research and therapeutic applications.
• Surface Functionalization: For modifying gold nanoparticles or other surfaces with thiol-reactive groups to create biosensor platforms.
• Diagnostic Reagent: As a component in the development of enzyme-linked immunosorbent assays (ELISA) and other immunoassays.
• Pharmaceutical Intermediate: In the synthesis of drug conjugates, such as antibody-drug conjugates (ADCs), where controlled linkage is critical.

Basic Information

Product Name	Sodium (2-Sulfonatoethyl)Methanethiosulfonate
CAS No.	155450-07-0
Molecular Formula	C3H6Na2O6S3
Molecular Weight	296.29 g/mol
Synonyms	MTSES; Sodium 2-Sulfonatoethyl Methanethiosulfonate; (2-Sulfonatoethyl) Methanethiosulfonate Sodium Salt; MTSEA-Sulfonate; 2-Sulfonatoethyl methanethiosulfonate; Sodium [(2-sulfoethyl)thio]methanesulfonate; Thiol-reactive sulfonate reagent
EINECS	Contact for details

Quality Control

Our Sodium (2-Sulfonatoethyl)Methanethiosulfonate is produced under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the exacting standards required for life science research. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive); keep the container tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccant.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 95%
Water Content	≤ 5.0%
Solubility	Freely soluble in water

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.