Description

tert-Butyl (Chroman-2-Ylmethyl)Carbamate is a specialized organic compound featuring a chroman scaffold protected by a Boc (tert-butoxycarbonyl) group. This structure makes it a valuable key chiral intermediate and building block in advanced organic synthesis, particularly for constructing complex molecules with defined stereochemistry. It is primarily sought by pharmaceutical R&D and fine chemical manufacturers for the development of active pharmaceutical ingredients (APIs) and other high-value compounds.

Application

• Pharmaceutical Intermediate: A critical chiral building block for the synthesis of novel drug candidates, particularly in therapeutic areas targeting the central nervous system and cardiovascular diseases.
• Asymmetric Synthesis: Used in the preparation of enantiomerically pure compounds due to its defined stereochemistry, essential for producing single-isomer pharmaceuticals.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and library synthesis in drug discovery programs.
• Fine Chemical Production: Employed in the multi-step synthesis of complex agrochemicals, flavors, fragrances, and advanced material precursors.
• Peptidomimetics & Protease Inhibitors: The chroman structure is analogous to privileged scaffolds used in designing enzyme inhibitors and bioactive peptides.

Basic Information

Product Name	tert-Butyl (Chroman-2-Ylmethyl)Carbamate
CAS No.	155427-84-2
Molecular Formula	C15H21NO3
Molecular Weight	263.33 g/mol
Synonyms	tert-Butyl N-[(2R)-chroman-2-ylmethyl]carbamate; (R)-tert-Butyl (chroman-2-ylmethyl)carbamate; tert-Butyl [(2R)-2H-1-benzopyran-2-ylmethyl]carbamate; Boc-Chroman-2-ylmethylamine; (R)-2-((tert-Butoxycarbonylamino)methyl)chroman; 155427-84-2; tert-Butyl (2R-chroman-2-ylmethyl)carbamate; N-Boc-2-(aminomethyl)chroman (R-enantiomer)
EINECS	Contact for details

Quality Control

Every batch of tert-Butyl (Chroman-2-Ylmethyl)Carbamate is manufactured under a strict quality management system. We employ advanced analytical techniques, including HPLC, GC, and NMR, to ensure high chemical and chiral purity suitable for demanding synthetic applications. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) detailing identity, purity, and impurity profiles are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.