Description

5-Methyl-2-(trifluoromethanesulfonyl)oxypyridine is a high-value trifluoromethanesulfonate (triflate) ester derivative of a substituted pyridine. This compound serves as a versatile and reactive synthetic intermediate, prized for its excellent leaving group properties in nucleophilic substitution and cross-coupling reactions. It is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing complex molecules, particularly those requiring the introduction of fluorinated or heterocyclic motifs.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of active pharmaceutical ingredients (APIs), especially for candidates containing pyridine or fluorinated structures.
• Agrochemical Synthesis: Used in the research and development of advanced herbicides, fungicides, and insecticides where its triflate group facilitates efficient coupling reactions.
• Material Science Research: Employed in the development of novel organic electronic materials, ligands for catalysis, and specialty polymers.
• Cross-Coupling Reactions: An effective substrate in palladium-catalyzed reactions such as Suzuki, Stille, and Negishi couplings to form new carbon-carbon bonds.
• Nucleophilic Substitution: The triflate group is readily displaced by a wide range of nucleophiles (e.g., amines, alkoxides), enabling functional group diversification.
• Chemical Research & Development: A valuable reagent for method development and exploring new synthetic pathways in academic and industrial R&D laboratories.

Basic Information

Product Name	5-Methyl-2-(Trifluoromethanesulfonyl)Oxypyridine
CAS No.	154447-03-7
Molecular Formula	C7H6F3NO3S
Molecular Weight	241.19 g/mol
Synonyms	2-Methoxy-5-methylpyridine Triflate; 5-Methyl-2-pyridyl Trifluoromethanesulfonate; 5-Methylpyridin-2-yl Triflate; 2-(Trifluoromethanesulfonyloxy)-5-methylpyridine; 5-Methyl-2-triflyloxypyridine; 2-Trifluoromethanesulfonato-5-methylpyridine; 5-Methyl-2-(trifluoromethylsulfonyl)oxypyridine
EINECS	Contact for details

Quality Control

Our 5-Methyl-2-(trifluoromethanesulfonyl)oxypyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing including HPLC for purity, NMR and IR for structural confirmation, and residual solvent analysis to ensure it meets the high standards required for research and process chemistry. A detailed Certificate of Analysis (COA) is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.