Description

4‐Tert‐Butylphenyl Trifluoromethanesulfonate is a high-purity triflate ester derivative, serving as a versatile and reactive arylating agent in advanced organic synthesis. Its core value lies in its excellent leaving group properties, enabling efficient C-C and C-heteroatom bond formation under mild conditions. This compound is essential for R&D chemists and process development teams in the pharmaceutical, agrochemical, and specialty materials industries seeking to introduce the tert-butylphenyl moiety into complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), particularly in Suzuki-Miyaura and other cross-coupling reactions.
• Agrochemical Synthesis: Used in creating advanced herbicides, fungicides, and insecticides that incorporate sterically hindered aryl groups.
• Ligand & Catalyst Development: Serves as a precursor for synthesizing specialized phosphine ligands and organometallic catalysts.
• Material Science: Employed in the production of monomers and polymers for advanced electronic and optical materials.
• Chemical Research: A critical reagent in methodological development for new palladium-catalyzed transformations and nucleophilic aromatic substitution.
• Fine Chemical Production: Facilitates the scalable, high-yield introduction of the 4-tert-butylphenyl group into target molecules.

Basic Information

Product Name	4‐Tert‐Butylphenyl Trifluoromethanesulfonate
CAS No.	154318-75-9
Molecular Formula	C11H13F3O3S
Molecular Weight	282.28 g/mol
Synonyms	4-(tert-Butyl)phenyl Triflate; 1-(1,1-Dimethylethyl)-4-[(trifluoromethyl)sulfonyl]oxy]benzene; p-Tert-Butylphenyl Trifluoromethanesulfonate; 4-tert-Butylphenyl Triflate; Trifluoromethanesulfonic Acid 4-tert-Butylphenyl Ester; 4-tert-Butyl Phenyl Triflate; 4-Tert-Butyl Phenyl Trifluoromethanesulfonate
EINECS	Contact for details

Quality Control

Our 4‐Tert‐Butylphenyl Trifluoromethanesulfonate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive synthetic applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards, and our quality commitment ensures the material meets the stringent requirements for use as a pharmaceutical intermediate.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.