Description

tert-Butyl (4R-Cis)-6-[(Acetyloxy)Methyl]-2,2-Dimethyl-1,3-Dioxane-4-Acetate CAS NO 154026-95-6 is a high-purity chiral intermediate of significant importance in advanced organic synthesis. Its value lies in its role as a key building block for the production of complex, optically active pharmaceutical compounds, particularly those targeting cardiovascular and metabolic diseases. This compound is essential for research institutions and pharmaceutical manufacturers engaged in the development and scale-up of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A critical chiral synthon in the multi-step synthesis of complex drug molecules, especially statins and other lipid-regulating agents.
• Asymmetric Synthesis: Used in the construction of stereogenic centers for the production of enantiomerically pure compounds in medicinal chemistry research.
• Process Chemistry & Scale-Up: Serves as a reliable and high-quality starting material for process development and pilot-scale manufacturing of target APIs.
• Fine Chemical Production: Employed in the synthesis of specialty chemicals and advanced materials that require high stereochemical fidelity.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.
• Academic & Industrial R&D: Utilized in research laboratories for developing new synthetic methodologies and exploring novel chemical entities.

Basic Information

Product Name	tert-Butyl (4R-Cis)-6-[(Acetyloxy)Methyl]-2,2-Dimethyl-1,3-Dioxane-4-Acetate
CAS No.	154026-95-6
Molecular Formula	C16H26O7
Molecular Weight	330.37 g/mol
Synonyms	(4R,6R)-6-[(Acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester; (4R-Cis)-6-[(Acetyloxy)Methyl]-2,2-Dimethyl-1,3-Dioxane-4-Acetic Acid tert-Butyl Ester; tert-Butyl (4R,6R)-6-(Acetoxymethyl)-2,2-dimethyl-1,3-dioxane-4-acetate; (4R,6R)-Atorvastatin tert-Butyl Ester Intermediate; Atorvastatin tert-Butyl Ester Synthon; (4R-Cis)-1,1-Dimethylethyl 6-[(Acetyloxy)methyl]-2,2-dimethyl-1,3-dioxane-4-acetate; (4R,6R)-6-(Hydroxymethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid, 6-acetate, 1,1-dimethylethyl ester
EINECS	Contact for details

Quality Control

Our tert-Butyl (4R-Cis)-6-[(Acetyloxy)Methyl]-2,2-Dimethyl-1,3-Dioxane-4-Acetate is manufactured under strict quality systems suitable for pharmaceutical applications. We provide material that meets rigorous in-house specifications, with purity typically exceeding 98.5% (by HPLC). Certificates of Analysis (COA) detailing chiral purity, assay, and impurity profiles are available for every batch upon request, ensuring full traceability and compliance with your project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. For long-term storage, consider using desiccants or storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.5%
Chiral Purity (Chiral HPLC)	≥ 99.0% (4R,6R isomer)
Related Substances (HPLC)	Individual unknown impurity ≤ 0.5% Total impurities ≤ 1.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5% w/w

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.