Description

(4R-Cis)-6-Chloromethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetic Acid tert-Butyl Ester is a high-purity chiral building block and advanced pharmaceutical intermediate. It matters for its critical role in the stereoselective synthesis of complex active pharmaceutical ingredients (APIs), where its defined stereochemistry ensures the production of the desired enantiomerically pure compound. This product is essential for pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of novel therapeutics, particularly in areas requiring sophisticated organic synthesis.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of target drug molecules, particularly for cardiovascular and central nervous system (CNS) active compounds.
• Asymmetric Synthesis: Utilized in stereocontrolled chemical reactions to construct complex molecular architectures with high enantiomeric excess (ee).
• Process Chemistry: Serves as a critical raw material in the scale-up and optimization of API manufacturing processes under cGMP conditions.
• Research & Development: Used in academic and industrial laboratories for the discovery and development of new chemical entities and biological probes.
• Fine Chemical Production: Employed in the custom synthesis of specialty chemicals where a protected, functionalized dioxane moiety is required.

Basic Information

Product Name	(4R-Cis)-6-Chloromethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetic Acid tert-Butyl Ester
CAS No.	154026-94-5
Molecular Formula	C13H23ClO5
Molecular Weight	294.77 g/mol
Synonyms	tert-Butyl (4R-cis)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetate; (4R,6S)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid 1,1-dimethylethyl ester; Atorvastatin tert-butyl ester intermediate; (4R-Cis)-6-(Chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester; 154026-94-5; (R-cis)-6-Chloromethyl-2,2-dimethyl-1,3-dioxane-4-acetic acid tert-butyl ester; tert-Butyl (4R,6S)-6-(chloromethyl)-2,2-dimethyl-1,3-dioxane-4-acetate
EINECS	Contact for details

Quality Control

Our (4R-Cis)-6-Chloromethyl-2,2-Dimethyl-1,3-Dioxane-4-Acetic Acid tert-Butyl Ester is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high chemical purity, chiral integrity, and consistent performance. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are provided and available upon request to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and oxidizing agents. For long-term storage under inert atmosphere, please contact us for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.