Description

Tetrabutylammonium Tetrakis(trifluoromethyl)cuprate(III) is a highly specialized organocopper reagent used in advanced organic synthesis. This compound matters for its unique ability to act as a powerful trifluoromethylating agent, a critical transformation in pharmaceutical and agrochemical research. It is primarily needed by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and advanced materials industries for introducing the metabolically stable trifluoromethyl group into complex molecules.

Application

• Pharmaceutical Intermediate Synthesis: Key reagent for the late-stage introduction of the trifluoromethyl (CF3) group into drug candidates to enhance metabolic stability, lipophilicity, and bioavailability.
• Agrochemical Development: Used in the synthesis of novel herbicides, fungicides, and insecticides where the CF3 group is a critical active moiety.
• Advanced Material Precursor: Employed in the synthesis of fluorinated organic semiconductors, liquid crystals, and polymers with tailored electronic and surface properties.
• Catalytic Reaction Development: Serves as a stoichiometric or catalytic source of CF3- equivalent in cross-coupling and nucleophilic substitution reactions under mild conditions.
• Radiopharmaceutical Labeling: Potential use in the synthesis of 18F-labeled compounds for Positron Emission Tomography (PET) imaging via related chemistry.
• Academic & Industrial Research: A valuable tool for methodology development in organofluorine and organometallic chemistry.

Basic Information

Product Name	Tetrabutylammonium Tetrakis(trifluoromethyl)cuprate(III)
CAS No.	152376-94-8
Molecular Formula	C20H36CuF12N
Molecular Weight	598.04 g/mol
Synonyms	Tetrabutylammonium Trifluoromethylcuprate(III); TBATFMC; Tetrabutylammonium (Trifluoromethyl)cuprate; (Trifluoromethyl)copper(III) Tetrabutylammonium Salt; N,N,N-Tributyl-1-butanaminium (OC-6-11)-tris(trifluoromethyl)cuprate(1-); Tetra-n-butylammonium Tetrakis(trifluoromethyl)cuprate(III)
EINECS	Contact for details

Quality Control

Every batch of Tetrabutylammonium Tetrakis(trifluoromethyl)cuprate(III) is manufactured and handled under strict inert atmosphere conditions to ensure stability and activity. Our products undergo rigorous quality testing, including NMR and titration assays, to ensure compliance with exacting R&D standards. Certificates of Analysis (COA) detailing purity, identity, and moisture content are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C in a freezer. This material is hygroscopic (moisture-sensitive) and easily oxidized; prolonged exposure to air, moisture, or elevated temperatures will lead to decomposition. Keep container tightly sealed when not in use.

Specification

Item	Specification
Appearance	Off-white to beige powder or crystalline solid
Identification (NMR)	Conforms to structure
Assay (Titration)	≥ 95%
Moisture Content (KF)	≤ 1.0%
Solubility	Soluble in common organic solvents (e.g., THF, DMF, acetonitrile)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.