Description

4-Methyl-2-Oxo-2H-Chromen-7-Yl Tosyl-L-Leucinate is a specialized chemical intermediate of significant interest in advanced organic synthesis. This compound is valued for its role as a protected amino acid derivative, enabling precise molecular construction in complex chemical environments. It is primarily utilized by research institutions and pharmaceutical development companies engaged in the synthesis of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex drug candidates and active pharmaceutical ingredients (APIs).
• Peptide Chemistry: Used in the preparation of modified peptides and peptidomimetics due to its protected L-leucine moiety.
• Protease Inhibitor Research: Serves as a precursor or model compound in the development of enzyme inhibitors.
• Chemical Biology Probes: Employed in the creation of fluorescent or activity-based probes, leveraging the coumarin (chromen) core.
• Academic & Industrial R&D: Utilized in research laboratories for methodological development and exploring new synthetic pathways.

Basic Information

Product Name	4-Methyl-2-Oxo-2H-Chromen-7-Yl Tosyl-L-Leucinate
CAS No.	152061-78-4
Molecular Formula	C24H25NO7S
Molecular Weight	471.52 g/mol
Synonyms	7-[(4-Methyl-2-oxo-2H-chromen-7-yl)oxy]-N-[(4-methylphenyl)sulfonyl]-L-leucinate; L-Leucine, N-[(4-methylphenyl)sulfonyl]-, 7-[(4-methyl-2-oxo-2H-1-benzopyran-7-yl)oxy] ester; Tosyl-L-leucine 4-methylcoumarin-7-yl ester; 4-Methylumbelliferyl tosyl-L-leucinate; Coumarin-derived leucine tosylate ester; Protease substrate analog; Chromogenic leucine derivative.
EINECS	Contact for details

Quality Control

Our production of 4-Methyl-2-Oxo-2H-Chromen-7-Yl Tosyl-L-Leucinate adheres to stringent quality protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized using advanced analytical techniques including HPLC, NMR, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); ensure the container is kept tightly sealed in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms to reference spectrum
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.