Description

4-Chlorophenylzinc Iodide is a versatile organozinc reagent, a key building block in modern synthetic organic chemistry. Its value lies in enabling highly selective carbon-carbon bond formation, particularly in Negishi cross-coupling reactions, which are critical for constructing complex molecular architectures. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require reliable, high-purity intermediates for developing active ingredients and functional molecules.

Application

• Pharmaceutical Intermediate Synthesis: A crucial reagent for introducing the 4-chlorophenyl moiety into target molecules during the research and development of new drug candidates and active pharmaceutical ingredients (APIs).
• Agrochemical Manufacturing: Used in the synthesis of herbicides, fungicides, and insecticides where the chlorophenyl group is a key structural component.
• Negishi Cross-Coupling Reactions: Serves as a superior organometallic coupling partner with various organic halides (aryl, vinyl, benzyl) in the presence of palladium or nickel catalysts to form biaryl and other complex structures.
• Ligand and Material Science: Employed in the preparation of specialized ligands for catalysis and as a precursor for advanced organic electronic materials.
• Fine Chemical Production: Facilitates the synthesis of complex, high-value specialty chemicals used in flavors, fragrances, and dyes.
• Academic and R&D Laboratories: A fundamental tool for methodological development in organic synthesis and for exploring new catalytic systems.

Basic Information

Item	Detail
Product Name	4-Chlorophenylzinc Iodide
CAS No.	151073-70-0
Molecular Formula	C6H4ClZnI
Molecular Weight	303.85 g/mol
Synonyms	4-Chlorophenylzinc Iodide; (4-Chlorophenyl)zinc Iodide; Zinc, (4-chlorophenyl)iodo-; p-Chlorophenylzinc Iodide; 1-Chloro-4-(iodozincio)benzene; Chlorophenylzinc Iodide (4-); Iodo(4-chlorophenyl)zinc
EINECS	Contact for details

Quality Control

Our 4-Chlorophenylzinc Iodide is manufactured under stringent quality control protocols to ensure batch-to-batch consistency and high reactivity. Each lot is analyzed to confirm identity, purity, and solution concentration (typically supplied as a solution in THF or other ethers). Certificates of Analysis (COA) are provided, detailing key parameters such as assay (by titration), residual zinc content, and halide concentration. We adhere to cGMP principles where applicable to support our clients in regulated industries.

Storage

Preserve in a tightly closed container, protected from light. This product is hygroscopic (moisture-sensitive) and easily oxidized (store under inert atmosphere). It is typically supplied as a solution and must be stored under a dry, inert gas (argon or nitrogen) at 2-8°C. For long-term stability, keep the sealed container in a cool, dry, well-ventilated area away from incompatible materials. Always handle using standard Schlenk line or glovebox techniques to exclude air and moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Identification (IR)	Conforms to structure
Assay (Titration)	0.5 M in THF (or as specified)
Purity (GC/HPLC)	≥ 95% (on solvent-free basis)
Moisture (KF)	< 500 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.