Description

(3R)-3-(n-Boc-Amino)-1-Chloro-4-Phenyl-2-Butanone CAS NO 150935-37-8 is a high-purity chiral building block featuring a protected amine group and a reactive chloro-ketone moiety. This compound matters as a critical intermediate for the stereoselective synthesis of complex pharmaceutical molecules, particularly in the development of protease inhibitors and other bioactive compounds. Pharmaceutical R&D and fine chemical synthesis laboratories need it to construct specific molecular architectures with high enantiomeric purity, ensuring the efficacy and safety of final drug candidates.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the synthesis of protease inhibitors, such as HIV-1 protease inhibitors.
• Peptidomimetic Research: Used in constructing non-peptide scaffolds that mimic peptide structure and function.
• Asymmetric Synthesis: Serves as a precursor for introducing the (3R)-3-amino functionality into target molecules under mild conditions.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies and lead optimization for new drug candidates.
• Custom Synthesis: A starting material for contract research and manufacturing organizations (CROs/CMOs) producing specialized fine chemicals.
• Academic Research: Utilized in methodological development for new asymmetric transformations and protecting group strategies.

Basic Information

Product Name	(3R)-3-(n-Boc-Amino)-1-Chloro-4-Phenyl-2-Butanone
CAS No.	150935-37-8
Molecular Formula	C15H20ClNO3
Molecular Weight	297.78 g/mol
Synonyms	1-Chloro-4-phenyl-2-butanone, 3-[(1,1-Dimethylethoxy)carbonyl]amino]-, (3R)-; (3R)-3-[(tert-Butoxycarbonyl)amino]-1-chloro-4-phenylbutan-2-one; (R)-3-(Boc-amino)-1-chloro-4-phenyl-2-butanone; Boc-(R)-3-Amino-1-chloro-4-phenyl-2-butanone; tert-Butyl (R)-(3-chloro-2-oxo-4-phenylbutyl)carbamate; N-Boc-(3R)-3-Amino-1-chloro-4-phenyl-2-butanone; 150935-37-8; A chiral chloro ketone Boc-protected amine.
EINECS	Contact for details

Quality Control

Our (3R)-3-(n-Boc-Amino)-1-Chloro-4-Phenyl-2-Butanone is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity assessment, to ensure compliance with exacting standards for pharmaceutical intermediates. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment to guarantee traceability and support your regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability and purity. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.