Description

2,2-Bis[(4R)-4-Isopropyl-2-Oxazolin-2-Yl]Propane is a high-purity, chiral bis(oxazoline) ligand, a critical class of organocatalysts and auxiliaries in asymmetric synthesis. Its value lies in enabling precise stereochemical control for the production of enantiomerically pure pharmaceuticals and fine chemicals. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors seeking to develop novel synthetic routes with high enantioselectivity.

Application

• Asymmetric Catalysis: As a chiral ligand for transition metals (e.g., Cu, Zn, Mg) in enantioselective cyclopropanation, Diels-Alder, and aldol reactions.
• Pharmaceutical Intermediates: Key component in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs) and complex natural products.
• Agrochemical Synthesis: Used in the development of chiral herbicides, fungicides, and pesticides with improved efficacy and environmental profiles.
• Material Science: Potential building block for chiral polymers and frameworks with specialized optical or separation properties.
• Academic & Industrial R&D: A versatile tool for methodological development in organic synthesis and catalysis research.
• Scale-up Process Development: Suitable for optimization from laboratory-scale discovery to pilot plant production of chiral compounds.

Basic Information

Product Name	2,2-Bis[(4R)-4-Isopropyl-2-Oxazolin-2-Yl]Propane
CAS No.	150529-94-5
Molecular Formula	C17H30N2O2
Molecular Weight	294.44 g/mol
Synonyms	(R,R)-2,2'-Isopropylidenebis(4-isopropyl-2-oxazoline); (4R,4'R)-2,2'-(2-Methylpropane-2,2-diyl)bis(4-(propan-2-yl)-4,5-dihydrooxazole); (R,R)-2,2'-Dimethyl-4,4'-bis(isopropyl)-1,3-dioxolane-4,4'-diylbis(2-oxazoline); Chiral BOX Ligand; (R)-4-Isopropyl-2-(2-((R)-4-isopropyl-4,5-dihydrooxazol-2-yl)propan-2-yl)-4,5-dihydrooxazole; Bis[(4R)-4-isopropyl-4,5-dihydrooxazol-2-yl]dimethylmethane
EINECS	Contact for details

Quality Control

Our 2,2-Bis[(4R)-4-Isopropyl-2-Oxazolin-2-Yl]Propane is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification by HPLC, to ensure compliance with exacting R&D and process chemistry standards. Certificates of Analysis (COA) detailing identity, assay, enantiomeric excess, and impurity profiles are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage and to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.