Description

4-Chlorobenzylzinc Chloride is a versatile organozinc reagent, specifically a benzylzinc halide, widely used in modern synthetic organic chemistry. Its primary value lies in enabling efficient carbon-carbon bond formation through cross-coupling reactions, offering a more stable and selective alternative to other organometallic species. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials sectors who require reliable building blocks for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate Synthesis: A key reagent for introducing the 4-chlorobenzyl moiety into target molecules during the research and development of active pharmaceutical ingredients (APIs).
• Negishi Cross-Coupling Reactions: Used in palladium-catalyzed couplings with organic halides (aryl, vinyl, alkynyl) to form new C-C bonds with high fidelity and functional group tolerance.
• Agrochemical Compound Manufacturing: Serves as a critical precursor in the synthesis of herbicides, fungicides, and other crop protection agents that incorporate chlorinated benzyl groups.
• Ligand and Catalyst Development: Employed in the preparation of specialized ligands and organometallic catalysts for asymmetric synthesis and polymerization processes.
• Material Science Research: Used to synthesize monomers and functionalized polymers with specific electronic or structural properties derived from the chlorobenzyl unit.
• Fine Chemical Production: Facilitates the scalable, efficient production of specialty chemicals and complex organic compounds for various industrial applications.

Basic Information

Item	Details
Product Name	4-Chlorobenzylzinc Chloride
CAS No.	149923-10-4
Molecular Formula	C7H6Cl2Zn
Molecular Weight	226.39 g/mol
Synonyms	(4-Chlorobenzyl)zinc chloride; 1-(Chlorozinciomethyl)-4-chlorobenzene; Zinc, chloromethyl-p-chlorophenyl-; p-Chlorobenzylzinc chloride; 4-Chlorobenzylzinc chloride solution; (4-Chlorophenyl)methylzinc chloride
EINECS	Contact for details

Quality Control

Every batch of 4-Chlorobenzylzinc Chloride is produced and tested under stringent quality management protocols to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) detailing key parameters such as concentration, purity, and solvent content. Our quality commitment aligns with cGMP principles for advanced intermediates, ensuring traceability and documentation suitable for regulated industry applications.

Storage

Preserve in a tightly closed container, protected from light. This product is moisture-sensitive (hygroscopic) and easily oxidized; it must be stored under an inert atmosphere (argon or nitrogen) at recommended temperatures, typically between 2°C and 8°C for solutions. Handle and store only in compatible, dry organic solvents as supplied. Keep away from strong acids and oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow solution
Concentration (Typical)	0.5 M in THF or as specified
Assay (Titration)	≥ 95.0%
Identity (IR / NMR)	Conforms to reference standard
Solvent Content (GC)	Balance

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.