Description

Tetrahydropyran-4,4-Dicarboxylic Acid Dimethyl Ester is a high-purity, versatile diester building block used in advanced organic synthesis. This compound is valued for its rigid, oxygen-containing tetrahydropyran core, which serves as a key structural motif for constructing complex molecules with specific conformational properties. It is primarily utilized by research chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for applications ranging from medicinal chemistry to material science.

Application

• Pharmaceutical Intermediate: A crucial building block for synthesizing novel active pharmaceutical ingredients (APIs), particularly those requiring a conformationally locked, heterocyclic scaffold.
• Agrochemical Synthesis: Used in the research and development of new herbicides, fungicides, and insecticides, where its structure can contribute to biological activity and stability.
• Ligand and Catalyst Development: Serves as a precursor for creating chiral ligands and organocatalysts used in asymmetric synthesis.
• Polymer & Material Science: Acts as a monomer or cross-linking agent for developing specialty polymers with unique thermal or mechanical properties.
• Chemical Research: Employed in academic and industrial R&D for exploring new synthetic methodologies and constructing complex natural product analogs.
• Flavor & Fragrance Chemistry: Potential intermediate for synthesizing specific aroma compounds due to its oxygenated ring system.

Basic Information

Product Name	Tetrahydropyran-4,4-Dicarboxylic Acid Dimethyl Ester
CAS No.	149777-00-4
Molecular Formula	C10H16O6
Molecular Weight	232.23 g/mol
Synonyms	Dimethyl Tetrahydropyran-4,4-dicarboxylate; 4,4-Bis(methoxycarbonyl)tetrahydropyran; Tetrahydropyran-4,4-dicarboxylic acid dimethyl ester; 2,6-Dioxa-spiro[3.3]heptane-1,1-dicarboxylic acid dimethyl ester; THP-Dicarboxylic Acid Dimethyl Ester; 1,1-Dimethoxycarbonyltetrahydropyran-4-one (tautomer); Spiro[3.3]heptane-1,1-dicarboxylic acid, 2,6-dioxa-, dimethyl ester
EINECS	Contact for details

Quality Control

Our Tetrahydropyran-4,4-Dicarboxylic Acid Dimethyl Ester is manufactured under strict quality management systems. Each batch is subjected to rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our production adheres to cGMP principles where applicable, ensuring reliability for research and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from strong acids and incompatible organic solvents. For long-term storage under inert atmosphere, please contact our technical team for specific recommendations.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.