Description

Isogambogic Acid CAS NO 149655-52-7 is a bioactive caged xanthone derivative, a structural isomer of gambogic acid, known for its potent and specific biological activity. This compound is of significant interest for its role as a promising lead molecule in pharmaceutical research and development, particularly in the field of oncology. It is primarily utilized by research institutions, pharmaceutical companies, and biotechnology firms engaged in drug discovery, mechanism of action studies, and the development of novel therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a key reference standard and active pharmaceutical ingredient (API) intermediate in the discovery of new anticancer drugs.
• Biochemical Research: Used as a potent and selective inhibitor in studies targeting specific cellular pathways, such as apoptosis induction and heat shock protein 90 (Hsp90) inhibition.
• Preclinical Studies: Employed in in vitro and in vivo models to evaluate efficacy, pharmacokinetics, and toxicology profiles for potential therapeutic applications.
• Analytical Reference Standard: Essential for quality control and method development in analytical laboratories using techniques like HPLC and LC-MS for purity assessment and quantification.
• Natural Product Chemistry: Used as a high-purity isolate for structure-activity relationship (SAR) studies and the semi-synthesis of novel analogs.

Basic Information

Product Name	Isogambogic Acid
CAS No.	149655-52-7
Molecular Formula	C38H44O8
Molecular Weight	628.75 g/mol
Synonyms	Isogambogic acid; (1R,7R,8S,8aR)-8a-Hydroxy-8-(3-hydroxy-3-methylbut-1-en-2-yl)-1-[(2S,3R)-3-hydroxy-2-(hydroxymethyl)-3-methyloxiran-2-yl]-7-(3-methylbut-2-en-1-yl)-4,5,6,7,8,8a-hexahydro-1H-naphtho[2,3-c]furan-3,9-dione; Gambogic acid isomer; Caged xanthone derivative; NSC 757073
EINECS	Contact for details

Quality Control

Our Isogambogic Acid is produced under strict quality management systems to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization using HPLC, NMR, and MS to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label or COA. For long-term storage, consider storing desiccated at -20°C. The product is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥95.0%
Water Content (KF)	≤2.0%
Residue on Ignition	≤0.5%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.