Description

4,6-o-Ethylidene-2,3-Di-o-Chloroacetyl-β-D-Glucopyranose is a key protected sugar intermediate, specifically a glucopyranose derivative with ethylidene and chloroacetyl protecting groups. This compound is critical for synthetic chemists as it provides a versatile and reactive scaffold for the controlled synthesis of complex carbohydrates, nucleosides, and other bioactive molecules. It is primarily utilized by research institutions and pharmaceutical companies engaged in advanced organic synthesis, process development, and the production of fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a crucial building block in the synthesis of novel nucleoside analogs and antiviral/anticancer drug candidates.
• Carbohydrate Chemistry Research: Used as a protected starting material for the stereoselective construction of oligosaccharides and glycoconjugates.
• Fine Chemical Synthesis: Acts as a chiral precursor for the production of specialty chemicals and catalysts requiring specific sugar-based architectures.
• Glycobiology Studies: Employed in the development of probes and inhibitors for studying enzyme mechanisms and biological recognition processes.
• Process Chemistry: Utilized in scale-up and optimization routes for the manufacturing of complex active pharmaceutical ingredients (APIs).

Basic Information

Product Name	4,6-o-Ethylidene-2,3-Di-o-Chloroacetyl-β-D-Glucopyranose
CAS No.	149403-65-6
Molecular Formula	C₁₄H₁₈Cl₂O₈
Molecular Weight	385.19 g/mol
Synonyms	2,3-Di-O-chloroacetyl-4,6-O-ethylidene-β-D-glucopyranose; 4,6-O-Ethylidene-2,3-di-O-chloroacetyl-β-D-glucopyranose; 1,2,3,4-Di-O-isopropylidene-6-O-trityl-α-D-galactopyranose (related intermediate); Ethylidene-protected glucopyranose chloroacetate; β-D-Glucopyranose, 4,6-O-ethylidene-2,3-bis-O-(chloroacetyl)-; Chloroacetylated ethylidene glucose
EINECS	Contact for details

Quality Control

Our 4,6-o-Ethylidene-2,3-Di-o-Chloroacetyl-β-D-Glucopyranose is produced under a strict quality management system. Every batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation by NMR and IR spectroscopy, to ensure it meets the high standards required for research and synthesis. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting key specifications such as assay purity and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed under anhydrous conditions to prevent degradation. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.