Description

1-Bromo-4-(Chloromethyl)-2-Methylbenzene is a versatile halogenated aromatic building block of significant importance in advanced organic synthesis. Its bifunctional nature, featuring both bromine and chloromethyl reactive sites, makes it a critical intermediate for constructing complex molecular architectures. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of active ingredients and novel chemical entities.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for molecules requiring substituted benzyl or aryl halide motifs.
• Agrochemical Synthesis: Used in the production of herbicides, fungicides, and insecticides where its halogenated structure can be further functionalized.
• Ligand and Catalyst Development: Serves as a starting material for the preparation of specialized ligands used in metal-catalyzed cross-coupling reactions.
• Material Science Research: Employed in the synthesis of monomers for specialty polymers, liquid crystals, and organic electronic materials.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags due to its reactive halogen handles for bioconjugation.
• Custom Synthesis and R&D: A valuable reagent for contract research organizations (CROs) and academic laboratories exploring new synthetic methodologies.

Basic Information

Product Name	1-Bromo-4-(Chloromethyl)-2-Methylbenzene
CAS No.	149104-97-2
Molecular Formula	C8H8BrCl
Molecular Weight	219.51 g/mol
Synonyms	4-Bromo-α-chloro-o-xylene; 2-Methyl-4-bromobenzyl chloride; 1-Bromo-4-(chloromethyl)-2-methyl-benzene; (4-Bromo-2-methylphenyl)methyl chloride; 2-Methyl-4-bromobenzylchloride; α-Chloro-4-bromo-o-xylene; 4-Bromo-2-methylbenzyl chloride; Benzene, 1-bromo-4-(chloromethyl)-2-methyl-
EINECS	Contact for details

Quality Control

Our 1-Bromo-4-(Chloromethyl)-2-Methylbenzene is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity and consistency, meeting the stringent requirements of research and process chemistry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to guarantee traceability and support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. This material is moisture-sensitive; ensure containers are kept tightly sealed to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Melting Point	Contact for details
Related Substances (HPLC)	Total impurities ≤ 3.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.