Description

(E)-4,4,5,5,5-Pentafluoropent-2-En-1-Ol is a high-value fluorinated organic building block characterized by its terminal alcohol and pentafluoroalkyl-substituted alkene functionality. This compound is critical for introducing fluorine atoms into target molecules, a key strategy for modulating their physical, chemical, and biological properties. It is primarily utilized by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors to create novel compounds with enhanced stability, bioavailability, or specific material characteristics.

Application

• Pharmaceutical Intermediate: Serves as a key synthon in the development of active pharmaceutical ingredients (APIs), particularly for introducing lipophilic fluorine motifs to improve metabolic stability and membrane permeability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where fluorination can enhance efficacy and environmental persistence.
• Liquid Crystal & OLED Materials: Acts as a precursor for fluorinated components in electronic display materials, leveraging the fluorine atoms to influence dielectric anisotropy and molecular alignment.
• Polymer & Surface Modification: Employed to synthesize fluorinated monomers or as a grafting agent to impart oil-repellency, chemical resistance, and low surface energy to polymers and coatings.
• Cross-Coupling Reactions: The alkene and alcohol groups make it a versatile partner in Suzuki, Heck, and other metal-catalyzed cross-coupling reactions to construct complex fluorinated architectures.
• Click Chemistry & Bioconjugation: The terminal alcohol can be further functionalized (e.g., to azides or alkynes) for use in bioorthogonal conjugation strategies for labeling and drug delivery systems.

Basic Information

Product Name	(E)-4,4,5,5,5-Pentafluoropent-2-En-1-Ol
CAS No.	148757-93-1
Molecular Formula	C5H5F5O
Molecular Weight	176.09 g/mol
Synonyms	(E)-4,4,5,5,5-Pentafluoro-2-penten-1-ol; 4,4,5,5,5-Pentafluoropent-2-en-1-ol; 2-Penten-1-ol, 4,4,5,5,5-pentafluoro-, (E)-; (E)-Pentafluoropentenol; trans-4,4,5,5,5-Pentafluoropent-2-en-1-ol
EINECS	Contact for details

Quality Control

Our (E)-4,4,5,5,5-Pentafluoropent-2-En-1-Ol is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and FTIR, to ensure identity, purity, and consistency. Certificates of Analysis (COA) detailing all specifications are provided with each shipment. We support custom synthesis and can tailor purity grades (e.g., >97%, >98%, >99%) to meet specific research or cGMP starting material requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under an inert atmosphere (e.g., nitrogen or argon) for long-term storage to prevent degradation. Keep away from strong oxidizers and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (GC/HPLC)	≥ 97.0%
Isomeric Purity ((E)-isomer)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.