Description

L-Phenylalanine, 5-(Acetyloxy)-n-Trifluoroacetyl-2-Trimethylstannyl, Ethyl Ester is a sophisticated, multi-functional organotin derivative of the essential amino acid L-phenylalanine. This compound is a critical advanced intermediate in the synthesis of complex molecules, particularly in pharmaceutical research and development. It is primarily needed by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for constructing novel compounds and exploring new synthetic pathways.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of potential drug candidates, especially those targeting the central nervous system or requiring specific chiral configurations.
• Peptidomimetic Research: Used to introduce modified phenylalanine residues into peptide analogs to enhance stability, bioavailability, or binding affinity.
• Organometallic Catalyst Precursor: Serves as a precursor or ligand in catalytic systems for cross-coupling reactions (e.g., Stille coupling) due to the presence of the trimethylstannyl group.
• Agrochemical Synthesis: Employed in the research and development of advanced pesticides and herbicides that require specific amino acid-based architectures.
• Chemical Biology Probes: Useful for labeling or modifying biomolecules to study protein interactions, enzyme mechanisms, or cellular pathways.
• Material Science Research: Potential monomer or additive for creating specialized polymers with unique properties derived from its aromatic and organometallic functionalities.

Basic Information

Product Name	L-Phenylalanine, 5-(Acetyloxy)-n-Trifluoroacetyl-2-Trimethylstannyl, Ethyl Ester
CAS No.	148613-10-9
Molecular Formula	C18H22F3NO5Sn
Molecular Weight	504.07 g/mol
Synonyms	Ethyl (2S)-2-[(Trifluoroacetyl)amino]-3-[5-(acetyloxy)-2-(trimethylstannyl)phenyl]propanoate; L-Phenylalanine, 5-(acetyloxy)-N-trifluoroacetyl-2-(trimethylstannyl)-, ethyl ester; 2-Trimethylstannyl-5-acetoxy-N-trifluoroacetyl-L-phenylalanine ethyl ester; N-Trifluoroacetyl-O5-acetyl-2-trimethylstannyl-L-tyrosine ethyl ester; Modified L-Tyrosine Ethyl Ester Organotin Derivative; Sn-Modified Fmoc-Phe(OAc)-OtBu analog (contextual); Advanced Stille Coupling Reagent; Contact for details on additional trade names.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and reliability for sensitive synthetic applications. Quality is verified through analytical techniques including HPLC, NMR (1H, 13C, 19F), and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your quality and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C (refrigerated) or as indicated on the label or COA. This compound is moisture-sensitive and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability. Keep away from strong acids/bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95% (Area %)
Assay	Contact for details
Specific Rotation	Contact for details
Heavy Metals	< 20 ppm
Residual Solvents	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.