Description

(25,3R,45,55,65)-2-(4-(Hydroxymethyl)-2-Nitrophenoxy)-6-(Methoxycarbonyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate is a high-purity, synthetically derived carbohydrate derivative with a protected hydroxyl group framework. This compound is a critical advanced pharmaceutical intermediate valued for its precise stereochemistry and functional group arrangement, enabling the synthesis of complex bioactive molecules. It is primarily utilized by research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in developing novel therapeutics and diagnostic agents.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of complex drug candidates, particularly in antiviral and anticancer research.
• Glycochemistry Research: Used in the study and synthesis of modified sugars, nucleosides, and glycosylation precursors.
• Proteomics & Diagnostics: Serves as a precursor for labeling reagents or affinity tags used in biomolecular analysis and assay development.
• Chemical Biology Probes: Employed in the development of activity-based probes to study enzyme function and metabolic pathways.
• Process Chemistry Development: Used for scaling up synthetic routes in pilot plants and optimizing manufacturing processes for active pharmaceutical ingredients (APIs).

Basic Information

Item	Details
Product Name	(25,3R,45,55,65)-2-(4-(Hydroxymethyl)-2-Nitrophenoxy)-6-(Methoxycarbonyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate
CAS No.	148579-94-6
Molecular Formula	C24H27NO13
Molecular Weight	537.47 g/mol
Synonyms	1,2,3-Tri-O-acetyl-5-O-(4-(hydroxymethyl)-2-nitrophenyl)-α-D-ribofuranose; 5-O-[4-(Hydroxymethyl)-2-nitrophenyl]-1,2,3-tri-O-acetyl-α-D-ribofuranose; α-D-Ribofuranose, 5-O-[4-(hydroxymethyl)-2-nitrophenyl]-, 1,2,3-triacetate; 2-Nitrophenyl-α-D-ribofuranoside triacetate derivative; HMNPA-α-D-ribofuranoside triacetate; Photolabile protecting group precursor; (2R,3R,4R,5R)-2-[(4-(Hydroxymethyl)-2-nitrophenoxy)methyl]-5-(methoxycarbonyl)tetrahydrofuran-3,4-diyl diacetate (related isomer)
EINECS	Contact for details

Quality Control

Our production of (25,3R,45,55,65)-2-(4-(Hydroxymethyl)-2-Nitrophenoxy)-6-(Methoxycarbonyl)Tetrahydro-2H-Pyran-3,4,5-Triyl Triacetate adheres to stringent quality management protocols. Every batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for stereochemical integrity, and NMR for structural confirmation. We provide a detailed Certificate of Analysis (COA) with each shipment, ensuring traceability and compliance with research-grade specifications. Our quality system is designed to support GMP-for-intermediate requirements for advanced pharmaceutical manufacturing.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent decomposition. Keep the container sealed in a dry environment to minimize exposure to atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity	≤ 0.5%
Total Impurities	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.