Description

Oxetan-3-Yl Methanesulfonate is a high-purity chemical building block and versatile alkylating agent. This compound is critical for the synthesis of complex molecules, particularly in advanced pharmaceutical research and development. It is primarily utilized by medicinal chemists and process development scientists in the pharmaceutical, agrochemical, and specialty chemical industries for introducing the oxetane moiety, a valuable motif for modulating physicochemical properties.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of active pharmaceutical ingredients (APIs), especially in oncology and antiviral drug candidates.
• Medicinal Chemistry: Used in structure-activity relationship (SAR) studies to incorporate the oxetane ring, which can improve metabolic stability, solubility, and potency.
• Bioconjugation & Linker Chemistry: Serves as a reactive handle for attaching payloads in antibody-drug conjugates (ADCs) and other targeted therapies.
• Agrochemical Synthesis: Intermediate in the production of novel herbicides, fungicides, and insecticides with enhanced efficacy.
• Material Science Research: Monomer or cross-linking agent for developing polymers with unique thermal and mechanical properties.
• Process Chemistry: Scalable reagent for the GMP manufacturing of clinical trial materials and commercial APIs.

Basic Information

Product Name	Oxetan-3-Yl Methanesulfonate
CAS No.	148430-81-3
Molecular Formula	C5H10O4S
Molecular Weight	166.20 g/mol
Synonyms	3-Oxetanyl methanesulfonate; Oxetan-3-yl mesylate; 3-Methanesulfonyloxyoxetane; 3-Hydroxyoxetane methanesulfonate; Mesyloxymethyl oxirane; Oxetane-3-yl methyl sulfonate; (Oxetan-3-yloxy)methanesulfonate
EINECS	Contact for details

Quality Control

Our Oxetan-3-Yl Methanesulfonate is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles. We adhere to relevant ICH guidelines and can support regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at 2-8°C or as indicated on the label. Due to its hygroscopic nature, the container should be kept sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent moisture absorption and decomposition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Any single unknown impurity	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.