Description

Mpeg-2000-Dspe CAS NO 147867-65-0 is a high-purity, functionalized polyethylene glycol (PEG) derivative, specifically a phospholipid-PEG conjugate. This compound is critical for creating stable, biocompatible, and targeted delivery systems in advanced pharmaceutical and biomedical applications. It is primarily needed by research institutions and manufacturers in the pharmaceutical, biotechnology, and advanced materials sectors for developing next-generation therapeutics and diagnostic agents.

Application

• Liposome and Nanoparticle Surface Functionalization: Used to impart stealth properties (PEGylation) to lipid-based drug delivery vehicles, enhancing circulation time and reducing immune clearance.
• Targeted Drug Delivery Systems: Serves as a key linker molecule for attaching targeting ligands (e.g., antibodies, peptides) to liposomes or micelles for site-specific therapy.
• Diagnostic Imaging Agent Formulation: Employed in the development of contrast agents for MRI, ultrasound, or fluorescence imaging to improve stability and biodistribution.
• Bioconjugation and Protein Modification: Acts as a heterobifunctional crosslinker for coupling biomolecules to surfaces or other molecules while maintaining solubility and reducing immunogenicity.
• Gene Delivery Vector Stabilization: Incorporated into lipid nanoparticles (LNPs) for mRNA or siRNA delivery to improve colloidal stability and transfection efficiency.
• Biomaterial and Hydrogel Modification: Used to enhance the biocompatibility and functionality of synthetic scaffolds for tissue engineering.

Basic Information

Product Name	Mpeg-2000-Dspe
CAS No.	147867-65-0
Molecular Formula	C₁₀₈H₂₁₀N₂O₅₀P (Typical, based on average PEG chain length)
Molecular Weight	~2000 g/mol (PEG average) + 790.05 g/mol (DSPE moiety)
Synonyms	1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)-2000]; DSPE-PEG(2000); DSPE-PEG2000; DSPE-mPEG 2000; 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine-N-[methoxy(polyethylene glycol)] (avg MW 2000); Phospholipid-PEG conjugate; mPEG-DSPE; PEGylated DSPE; Poly(ethylene glycol) methyl ether distearoylphosphatidylethanolamine
EINECS	Contact for details

Quality Control

Our Mpeg-2000-Dspe is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing to ensure high purity, consistent molecular weight distribution, and functional integrity. Specifications are aligned with standards relevant to pharmaceutical excipient development. A comprehensive Certificate of Analysis (COA) detailing purity, endotoxin levels, and functional group analysis is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below under an inert atmosphere (e.g., argon or nitrogen) for long-term stability. This product is hygroscopic (moisture-sensitive). Allow the sealed vial to equilibrate to room temperature before opening to prevent condensation. For short-term use, store desiccated at 2-8°C.

Specification

Item	Specification
Appearance	White to off-white waxy solid or powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Average Molecular Weight (SEC-MALS)	2700 - 3100 g/mol
Polydispersity Index (PDI)	≤ 1.05
Functional Substitution	≥ 90%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.