Description

1-Propanol, 2-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]-2-Methyl- is a specialized organosilicon-protected alcohol derivative, serving as a critical building block in advanced organic synthesis. Its primary value lies in providing a robust, orthogonal protecting group for hydroxyl functions, enabling complex multi-step reactions with high selectivity and yield. This compound is essential for researchers and process chemists in the pharmaceutical, agrochemical, and fine chemical industries who require precise control over molecular architecture during the synthesis of complex active ingredients and novel materials.

Application

• Pharmaceutical Intermediate: Key protecting group reagent in the multi-step synthesis of complex drug molecules, particularly for steroids, nucleotides, and other sensitive bioactive compounds.
• Peptide & Carbohydrate Chemistry: Used to selectively protect specific hydroxyl groups during the synthesis of complex peptides, oligosaccharides, and glycoconjugates.
• Agrochemical Synthesis: Intermediate in the production of advanced pesticides and herbicides where selective protection/deprotection sequences are required.
• Material Science Research: Building block for creating novel silicon-containing polymers, dendrimers, and functionalized surfaces with tailored properties.
• Asymmetric Synthesis: Employed in chiral pool syntheses and the preparation of enantiomerically pure intermediates due to the steric bulk of the tert-butyldiphenylsilyl (TBDPS) group.
• Process Chemistry Development: Used in route scouting and optimization for the scalable manufacture of high-value fine chemicals.

Basic Information

Product Name	1-Propanol, 2-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]-2-Methyl-
CAS No.	147509-22-6
Molecular Formula	C22H32O2Si
Molecular Weight	356.58 g/mol
Synonyms	2-Methyl-2-[[(tert-butyldiphenylsilyl)oxy]methyl]-1-propanol; (2-Hydroxy-1,1-dimethylethyl)methyl tert-Butyldiphenylsilyl Ether; 2-(tert-Butyldiphenylsilyloxymethyl)-2-methylpropan-1-ol; TBDPS Ether of 2-(Hydroxymethyl)-2-methyl-1-propanol; tert-Butyldiphenylsilyl 2-Hydroxy-1,1-dimethylethyl Methyl Ether; Neopentyl Glycol Derived TBDPS Ether; CAS 147509-22-6
EINECS	Contact for details

Quality Control

Every batch of 1-Propanol, 2-[[[(1,1-Dimethylethyl)Diphenylsilyl]Oxy]Methyl]-2-Methyl- is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the compound meets the high-purity standards required for sensitive synthetic applications. A detailed Certificate of Analysis (COA) is supplied with each shipment, confirming identity, purity, and absence of critical impurities. Our quality protocols are designed to support cGMP and ISO guidelines for advanced chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); containers must be kept tightly sealed and under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from strong oxidizing agents.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.