Description

4-Bromo-4,4-Difluorobutyric Acid is a versatile fluorinated organic building block characterized by its reactive bromine and carboxylic acid functional groups. This compound is of significant value in advanced organic synthesis, particularly for introducing difluoromethylene units and facilitating further functionalization. It is primarily sought by researchers and manufacturers in the pharmaceutical and agrochemical industries for the development of novel active ingredients and fine chemicals. Its unique structure makes it a key intermediate for constructing complex molecules with tailored properties.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing difluoromethylene (CF2) bioisosteres to modulate metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoroalkyl chain can enhance biological activity and environmental profile.
• Material Science Research: Serves as a monomer or precursor for developing specialty polymers and fluorinated materials with unique surface properties and chemical resistance.
• Organic Synthesis Reagent: Employed in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck) and nucleophilic substitution reactions to create complex carbon skeletons.
• Ligand and Catalyst Development: Useful for preparing novel fluorinated ligands for metal complexes used in catalysis and sensing applications.
• Fluorine Chemistry Research: A valuable tool for academic and industrial R&D focused on exploring new fluorination methodologies and the effects of fluorine substitution.

Basic Information

Product Name	4-Bromo-4,4-Difluorobutyric Acid
CAS No.	147345-36-6
Molecular Formula	C4H5BrF2O2
Molecular Weight	199.98 g/mol
Synonyms	4-Bromo-4,4-difluorobutanoic Acid; 4,4-Difluoro-4-bromobutyric Acid; Butyric acid, 4-bromo-4,4-difluoro-; 4-Bromo-4,4-difluorobutanoic acid; γ-Bromo-γ,γ-difluorobutyric Acid
EINECS	Contact for details

Quality Control

Our 4-Bromo-4,4-Difluorobutyric Acid is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and production applications. We employ advanced analytical techniques including HPLC, GC, NMR, and IR spectroscopy for comprehensive characterization. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming identity, purity, and impurity profiles. Our quality system is designed to meet the stringent requirements of cGMP and ISO standards for fine chemical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its light-sensitive nature, containers should be amber-colored or stored in dark conditions. For long-term storage, consider under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.