Description

Rocaglamide J CAS NO 147059-47-0 is a highly potent and specific natural product derivative belonging to the rocaglamide class of compounds. This compound matters for its significant role as a selective inhibitor of eukaryotic translation initiation, making it a powerful tool for probing cellular protein synthesis pathways and a promising scaffold for therapeutic development. It is primarily needed by researchers in pharmaceutical R&D, biotechnology, and academic institutions focused on oncology, virology, and molecular biology.

Application

• Biomedical Research: Used as a critical research chemical to study the mechanisms of protein synthesis inhibition, apoptosis, and cell cycle regulation.
• Anticancer Agent Development: Serves as a lead compound and reference standard in the discovery and validation of novel chemotherapeutic agents targeting translation initiation.
• Antiviral Studies: Employed in virology research to investigate host-directed antiviral strategies by suppressing viral protein production.
• Signal Transduction Pathway Analysis: Acts as a specific probe to dissect the role of translation in various cellular signaling cascades and stress responses.
• Pharmaceutical Reference Standard: Utilized as a high-purity analytical standard for quality control and method development in drug discovery pipelines.
• Chemical Biology: Provides a molecular tool for target identification, validation, and understanding the functional proteome.

Basic Information

Product Name	Rocaglamide J
CAS No.	147059-47-0
Molecular Formula	C29H31NO7
Molecular Weight	505.56 g/mol
Synonyms	Rocaglamide J; (-)-Rocaglamide J; Roc-J; 1H-Cyclopenta[b]benzofuran-1-acetamide, 8-[(1R,2R,3aS,8bS)-2,3,3a,8b-tetrahydro-2-hydroxy-1-[(3,4,5-trimethoxyphenyl)methyl]-1H-cyclopenta[b]benzofuran-8-yl]-N,N-dimethyl-, (1S)-; Flavagline derivative; Translation inhibitor FL3; Silvestrol analog
EINECS	Contact for details

Quality Control

Our Rocaglamide J is produced under stringent conditions to ensure the highest standards of purity and consistency, suitable for sensitive research applications. Each batch undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and potency. A detailed Certificate of Analysis (COA) is provided with every shipment, guaranteeing traceability and compliance with your research specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. Due to its hygroscopic nature, the container should be kept in a desiccated environment. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.