Description

Rocaglaol CAS NO 147059-46-9 is a bioactive natural product belonging to the rocaglamide class of compounds, known for its potent and specific biological activity. This compound is of significant interest for its role as a selective inhibitor of eukaryotic translation initiation, making it a powerful tool for biomedical research and drug discovery. It is primarily utilized by researchers in pharmaceutical development, oncology, and molecular biology for investigating protein synthesis pathways and developing novel therapeutic agents.

Application

• Biomedical Research: A critical tool for studying the mechanisms of eukaryotic translation initiation and cellular stress responses.
• Anticancer Agent Development: Serves as a lead compound and reference standard in the discovery and validation of new oncology therapeutics due to its potent antiproliferative effects.
• Pharmaceutical Reference Standard: Used for quality control, method development, and calibration in analytical laboratories within the pharmaceutical industry.
• Mechanistic Studies in Cell Biology: Employed to investigate signal transduction pathways, apoptosis, and other cell death mechanisms.
• Biochemical Assay Development: Utilized as a key component in high-throughput screening assays to identify new translation inhibitors.
• Academic Research: Fundamental research in universities and institutes exploring protein synthesis, gene expression, and natural product pharmacology.

Basic Information

Product Name	Rocaglaol
CAS No.	147059-46-9
Molecular Formula	C29H31NO7
Molecular Weight	505.56 g/mol
Synonyms	Rocaglaol; (-)-Rocaglaol; 1H-Cyclopenta[b]benzofuran-5-ol, 2,3,3a,8a-tetrahydro-1,8a-dihydroxy-6,8-dimethoxy-3-(1-methoxyethenyl)-2,5-dimethyl-, (1R,2R,3R,3aR,8aS)-; AG-L-596; Rocaglamide derivative; Flavagline compound
EINECS	Contact for details

Quality Control

Our Rocaglaol is produced and handled under strict quality management protocols to ensure batch-to-batch consistency and high purity, suitable for research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles, typically determined by HPLC, NMR, and MS. We adhere to relevant standards for research chemicals, ensuring reliable performance in your critical experiments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.