Description

5-(Trimethylstannyl)-2'-Deoxyuridine is a specialized organotin-modified nucleoside derivative, serving as a critical intermediate in advanced synthetic chemistry. Its core value lies in enabling precise structural modifications for the development of novel therapeutic agents and diagnostic probes. This high-purity compound is essential for researchers and manufacturers in pharmaceutical R&D, particularly in the fields of oncology and antiviral drug discovery, as well as in the synthesis of labeled compounds for molecular imaging.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of novel nucleoside analog prodrugs and antiviral/anticancer candidates.
• Radiopharmaceutical Precursor: Used in the development of radiolabeled (e.g., with 123I, 18F) compounds for Positron Emission Tomography (PET) imaging.
• Bioconjugation Chemistry: Facilitates site-specific labeling of oligonucleotides, peptides, and other biomolecules via Stille cross-coupling reactions.
• Chemical Biology Research: A tool compound for studying nucleic acid metabolism and for incorporating modified bases into DNA strands.
• Material Science: Potential precursor for creating functionalized surfaces or conductive polymers with integrated nucleoside motifs.

Basic Information

Product Name	5-(Trimethylstannyl)-2'-Deoxyuridine
CAS No.	146629-34-7
Molecular Formula	C12H20N2O5Sn
Molecular Weight	391.00 g/mol
Synonyms	5-(Trimethylstannyl)-2'-deoxyuridine; 2'-Deoxy-5-(trimethylstannyl)uridine; 1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)oxolan-2-yl]-5-(trimethylstannyl)pyrimidine-2,4-dione; dU-SnMe3; 5-(Trimethylstannyl)dU; 5-TMSn-dUrd; 5-(Trimethyltin)-2'-deoxyuridine
EINECS	Contact for details

Quality Control

Every batch of 5-(Trimethylstannyl)-2'-Deoxyuridine is manufactured under controlled conditions and undergoes rigorous analytical testing to ensure identity, purity, and consistency. Our quality commitment includes comprehensive characterization by NMR (1H, 13C), HPLC, and mass spectrometry. Certificates of Analysis (COA) detailing batch-specific results are provided and can be tailored to meet specific project or regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C under an inert atmosphere (e.g., argon or nitrogen) to prevent oxidation. Keep the container in a dry, cool, and well-ventilated place. For long-term storage, desiccate at -20°C.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.