Description

(R)-2-(Tetrahydrofuran-3-Yl)Acetic Acid is a high-value chiral building block and intermediate of significant importance in modern synthetic organic chemistry. Its core value lies in its stereochemically defined tetrahydrofuran moiety, which is a privileged structural motif found in numerous biologically active molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for the development of novel active pharmaceutical ingredients (APIs) and fine chemicals.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of complex drug candidates, especially those targeting central nervous system (CNS) disorders and infectious diseases.
• Agrochemical Synthesis: Used in the research and production of advanced pesticides and herbicides where specific stereochemistry is required for optimal activity.
• Asymmetric Catalysis Ligand Precursor: Serves as a starting material for the preparation of chiral ligands used in enantioselective catalytic reactions.
• Natural Product and Fragrance Synthesis: Employed in the total synthesis of natural products containing tetrahydrofuran rings and in creating specialty aroma chemicals.
• Academic and R&D Laboratories: A valuable reagent for methodological development in organic synthesis and medicinal chemistry research programs.
• Fine Chemical Production: Integral to the manufacture of custom, high-purity specialty chemicals for advanced material science applications.

Basic Information

Product Name	(R)-2-(Tetrahydrofuran-3-Yl)Acetic Acid
CAS No.	146255-25-6
Molecular Formula	C6H10O3
Molecular Weight	130.14 g/mol
Synonyms	(R)-2-(Oxolan-3-yl)acetic acid; (3R)-Tetrahydro-3-furanacetic Acid; (R)-Tetrahydrofuran-3-ylacetic Acid; (R)-3-Carboxymethyltetrahydrofuran; (R)-THF-3-Acetic Acid; (R)-2-(Tetrahydro-3-furanyl)acetic Acid; (R)-3-Furanacetic acid, tetrahydro-
EINECS	Contact for details

Quality Control

Our (R)-2-(Tetrahydrofuran-3-Yl)Acetic Acid is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical and advanced synthetic applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (assay), chiral excess, and impurity profiles is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption, which may affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.