Description

1,2,3-Pyridazinetricarboxylic Acid, Tetrahydro-, 1,2-Bis(1,1-Dimethylethyl) Ester, (3R)- is a high-purity, chiral synthetic intermediate of significant importance in advanced pharmaceutical research and development. Its value lies in its role as a sophisticated building block for constructing complex molecules with specific stereochemistry. This compound is primarily needed by R&D chemists and process development scientists in the pharmaceutical and agrochemical industries, where it facilitates the synthesis of novel active ingredients. The product is supplied with a CAS number of 146232-51-1.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of potential drug candidates, particularly for central nervous system (CNS) and cardiovascular targets.
• Agrochemical Research: Used in the development of novel, stereoselective pesticides and herbicides where specific enantiomeric activity is required.
• Asymmetric Catalysis Ligand Precursor: The protected carboxylic acid groups and defined stereocenter make it a valuable precursor for developing novel chiral ligands and catalysts.
• Fine Chemical Synthesis: Employed in multi-step organic syntheses for producing complex, high-value specialty chemicals.
• Academic & Institutional R&D: Utilized in university and research institute laboratories for methodological studies in heterocyclic and stereoselective chemistry.

Basic Information

Item	Details
Product Name	1,2,3-Pyridazinetricarboxylic Acid, Tetrahydro-, 1,2-Bis(1,1-Dimethylethyl) Ester, (3R)-
CAS No.	146232-51-1
Molecular Formula	C18H30N2O6
Molecular Weight	370.44 g/mol
Synonyms	(3R)-1,2-Bis(tert-butyl) 1,2,3,6-tetrahydro-1,2,3-pyridazinetricarboxylate; (3R)-1,2-Di-tert-butyl 1,2,3,6-tetrahydro-1,2,3-pyridazinetricarboxylate; (R)-1,2-Di-tert-butyl 1,2,3,6-tetrahydro-1,2,3-pyridazinetricarboxylate; Tetrahydro-1,2,3-pyridazinetricarboxylic Acid 1,2-Bis(1,1-dimethylethyl) Ester, (3R)-; 1,2-Di-tert-butyl (3R)-1,2,3,6-tetrahydro-1,2,3-pyridazinetricarboxylate; Chiral Pyridazine Derivative; tert-Butyl Ester of (R)-Tetrahydro-1,2,3-pyridazinetricarboxylic Acid
EINECS	Contact for details

Quality Control

Every batch of our 1,2,3-Pyridazinetricarboxylic Acid, Tetrahydro-, 1,2-Bis(1,1-Dimethylethyl) Ester, (3R)- undergoes rigorous analytical testing to ensure identity, purity, and chiral integrity. Our quality systems are designed to meet the stringent requirements of cGMP for advanced pharmaceutical intermediates. Standard testing includes chiral HPLC for enantiomeric excess (ee) verification, NMR for structural confirmation, and stringent control of residual solvents. A comprehensive Certificate of Analysis (COA) detailing all specifications and test results is provided with each shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). The compound is stable under these conditions but should be kept away from strong bases and organic solvents as indicated by its chemical properties. For long-term storage, consider inert atmosphere conditions to ensure optimal stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.