Description

4H-Pyran-4-One, 2,3-Dihydro-6-(Hydroxymethyl)-2-Methyl-, (2S)- (9Ci) is a high-purity chiral intermediate of significant interest in advanced organic synthesis. Its defined stereochemistry and functional group versatility make it a critical building block for the development of complex, biologically active molecules. This compound is primarily sought after by research institutions and manufacturers in the pharmaceutical and fine chemical industries for applications in drug discovery and process development.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of novel active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system and metabolic disorders.
• Asymmetric Synthesis: Utilized as a starting material or advanced intermediate in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in lead optimization and structure-activity relationship (SAR) studies to explore new chemical space and develop potent drug candidates.
• Fine Chemical Production: Used in the manufacture of specialty chemicals, agrochemicals, and high-value flavors & fragrances where precise stereochemistry is required.
• Academic & Process R&D: A valuable reagent for methodological development in organic chemistry and for scaling up synthetic routes under current Good Manufacturing Practices (cGMP).

Basic Information

Product Name	4H-Pyran-4-One, 2,3-Dihydro-6-(Hydroxymethyl)-2-Methyl-, (2S)- (9Ci)
CAS No.	146064-66-6
Molecular Formula	C7H10O3
Molecular Weight	142.15 g/mol
Synonyms	(2S)-2,3-Dihydro-6-(hydroxymethyl)-2-methyl-4H-pyran-4-one; (S)-2,3-Dihydro-6-(hydroxymethyl)-2-methyl-4H-pyran-4-one; (S)-6-(Hydroxymethyl)-2-methyl-2,3-dihydro-4H-pyran-4-one; (S)-Dihydro-6-(hydroxymethyl)-2-methyl-4H-pyran-4-one; (2S)-2-Methyl-6-(hydroxymethyl)-2,3-dihydro-4H-pyran-4-one; Chiral Dihydro-4H-pyran-4-one derivative; (S)-enantiomer of 6-(Hydroxymethyl)-2-methyl-2,3-dihydro-4H-pyran-4-one
EINECS	Contact for details

Quality Control

Our production of this chiral intermediate adheres to strict quality protocols to ensure batch-to-batch consistency and high enantiomeric excess. Quality is verified through comprehensive analytical methods including chiral HPLC, NMR, and mass spectrometry. A Certificate of Analysis (COA) detailing identity, purity, chiral purity, and impurity profile is provided with each shipment. We support development and commercial projects with material produced under quality management systems suitable for cGMP applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Complies with ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.