Description

Mes-Peg5- Thp is a specialized heterobifunctional polyethylene glycol (PEG) derivative featuring a methanesulfonyl (mesyl) group at one terminus and a tetrahydropyranyl (THP) protected hydroxyl group at the other. This compound is engineered to serve as a critical building block in the synthesis of complex, functionalized molecules, enabling precise conjugation and controlled release strategies. It is primarily utilized by researchers and process development scientists in the pharmaceutical, biotechnology, and advanced materials sectors for applications such as bioconjugation, prodrug development, and polymer modification.

Application

• Bioconjugation Linker: Used to attach drugs, dyes, or other functional molecules to proteins, peptides, or antibodies, leveraging the reactive mesyl group for selective coupling.
• Prodrug Synthesis: Serves as a key intermediate in designing prodrugs where the THP-protected PEG chain provides solubility and controlled release of the active pharmaceutical ingredient.
• Polymer Functionalization: Employed to introduce reactive sites or protected functional groups into PEG-based polymers and hydrogels for advanced material science applications.
• Chemical Biology Probes: Facilitates the creation of labeled probes for studying biological processes, where the PEG spacer reduces steric hindrance and improves pharmacokinetics.
• ADC (Antibody-Drug Conjugate) Development: Acts as a component in the linker-payload assembly for next-generation ADCs, aiming to improve stability and therapeutic index.
• Cross-linking Agent: Utilized in the preparation of cross-linked networks for drug delivery systems or biomaterials due to its bifunctional reactivity.

Basic Information

Product Name	Mes-Peg5- Thp
CAS No.	145927-73-7
Molecular Formula	C19H38O9S
Molecular Weight	442.57 g/mol
Synonyms	Methanesulfonyl-PEG5-THP; Mesyl-PEG5-THP; 2,5,8,11,14-Pentaoxaheptadecan-17-yl methanesulfonate, 16-(tetrahydro-2H-pyran-2-yloxy)-; THP-PEG5-Ms; 16-(Tetrahydro-2H-pyran-2-yloxy)-2,5,8,11,14-pentaoxaheptadecan-17-yl methanesulfonate; PEG5 spacer with Ms and THP ends; Heterobifunctional PEG derivative Ms-PEG5-THP
EINECS	Contact for details

Quality Control

Every batch of Mes-Peg5- Thp is manufactured under strict quality management protocols. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high purity and consistent performance for critical research and development applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with each shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	Colorless to pale yellow viscous liquid or solid
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 95%
Water Content (KF)	≤ 1.0%
Molecular Weight Confirmation (MS)	Conforms

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.