Description

2,3,3A,6,7,7A-Hexahydro-5',7A-Dimethyl-4-Hydroxy-Indene-(1R)-1'-Pentanoic Acid Methyl Ester 4-o-Trifluoromethanesulfonate is a high-purity, advanced pharmaceutical intermediate characterized by its specific stereochemistry and functional groups. This compound matters for its critical role as a key building block in the synthesis of complex, biologically active molecules, particularly in medicinal chemistry. It is primarily needed by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutic agents, where precise chemical structure and reliable purity are paramount for successful outcomes.

Application

• Pharmaceutical Intermediate: Serves as a crucial chiral synthon in the multi-step synthesis of proprietary drug candidates, especially in oncology and metabolic disease research.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies and lead optimization processes to develop new chemical entities with targeted biological activity.
• Process Chemistry Development: Employed in scaling up synthetic routes from laboratory to pilot plant scale, requiring consistent quality and supply.
• Asymmetric Synthesis: Utilized as a starting material or intermediate in catalytic asymmetric reactions due to its defined stereocenter.
• Contract Research & Manufacturing (CRO/CMO): Supplied to organizations providing custom synthesis and process development services for the global pharmaceutical industry.
• Reference Standard: Can be supplied as a high-purity analytical standard for method development and quality control in API manufacturing.

Basic Information

Product Name	2,3,3A,6,7,7A-Hexahydro-5',7A-Dimethyl-4-Hydroxy-Indene-(1R)-1'-Pentanoic Acid Methyl Ester 4-o-Trifluoromethanesulfonate
CAS No.	145372-34-5
Molecular Formula	C₁₈H₂₅F₃O₆S
Molecular Weight	426.45 g/mol
Synonyms	(1R)-1'-Pentanoic acid, 2,3,3a,6,7,7a-hexahydro-5',7a-dimethyl-4-hydroxy-indene-4-yl ester, 4-(trifluoromethanesulfonate); Methyl (1R)-2,3,3a,6,7,7a-hexahydro-5',7a-dimethyl-4-hydroxy-1H-indene-1-pentanoate 4-trifluoromethanesulfonate; Indene triflate derivative; Advanced pharmaceutical intermediate CAS 145372-34-5
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced under strict quality management systems. We employ state-of-the-art analytical techniques, including HPLC, GC, NMR, and chiral analysis, to ensure identity, purity, and enantiomeric excess meet stringent client specifications. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment, supporting regulatory filings and ensuring traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% e.e.
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.