Description

3-Methyl-2-Nitrophenyl Triflate, 2-Nitro-m-Tolyl Triflate is a high-purity, specialized triflate ester derivative used as a critical building block in advanced organic synthesis. This compound is valued for its role as a versatile electrophile and protecting group, enabling precise chemical transformations in complex molecule construction. It is primarily sought after by R&D chemists and process development scientists in the pharmaceutical, agrochemical, and advanced materials sectors for synthesizing novel active ingredients and functional intermediates.

Application

• Pharmaceutical Intermediate: A key electrophile in cross-coupling reactions (e.g., Suzuki, Stille) for constructing biaryl structures found in active pharmaceutical ingredients (APIs).
• Agrochemical Synthesis: Used in the development of novel herbicides, fungicides, and insecticides, leveraging its reactivity to introduce specific nitro-substituted aromatic motifs.
• Material Science Research: Serves as a precursor for functionalized monomers or ligands in the development of specialty polymers and advanced organic electronic materials.
• Chemical Biology & Proteomics: Employed as a reagent for modifying biomolecules or creating activity-based probes due to its reactivity as a leaving group.
• Catalyst & Ligand Development: Utilized in the synthesis of complex, nitrogen-containing ligands for transition metal catalysis.
• Custom Synthesis & Contract Manufacturing: A valuable starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing bespoke compounds for client projects.

Basic Information

Product Name	3-Methyl-2-Nitrophenyl Triflate, 2-Nitro-m-Tolyl Triflate
CAS No.	145209-21-8
Molecular Formula	C8H6F3NO5S
Molecular Weight	285.20 g/mol
Synonyms	2-Nitro-m-tolyl trifluoromethanesulfonate; 3-Methyl-2-nitrophenyl trifluoromethanesulfonate; 2-Nitro-3-methylphenyl triflate; (3-Methyl-2-nitrophenyl) trifluoromethanesulfonate; Trifluoromethanesulfonic acid 3-methyl-2-nitrophenyl ester; 2-Nitro-m-tolyl triflate; 2-Nitro-3-methylphenyl trifluoromethanesulfonate; m-Tolyl, 2-nitro-, triflate
EINECS	Contact for details

Quality Control

Our 3-Methyl-2-Nitrophenyl Triflate is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure high chemical purity and identity confirmation. A comprehensive Certificate of Analysis (COA) detailing purity, assay, and impurity profiles is provided with every shipment to guarantee batch-to-batch consistency and reliability for your critical synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent degradation. Keep away from incompatible materials such as strong bases and reducing agents.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.